Detection of hypothalamic neuropeptite levels involved in appetite regulation in aripiprazole treatment /

Özdemir, Serhat
Disruption or malfunctioning of neurotransmitter pathways, especially serotonergic and dopaminergic pathways are closely related to psychotic disorders such as schizophrenia. Antipsychotic medications are becoming widespread; however, in long term treatments, these drugs lead to considerable amount of weight gain as a side effect. Metformin, an antidiabetic drug, has previously been used to treat antipsychotic induced weight gain and aripiprazole has been defined as a neutral antipsychotic drug in terms of weight gain. Yet, the underlying action mechanisms of these drugs are still inadequately understood. Hypothalamic neuropeptides releasing from arcuate nucleus (ARC) are known to be responsible for appetite and energy metabolism regulation. The aim of this study is to investigate the alteration of candidate gene expression levels of hypothalamic neuro peptides, neuropeptide Y (NPY) and proopiomelanocortin (POMC) by administration of metformin and aripiprazole to male Wistar rats for 14 weeks. We hypothesized that metformin may cause an increase in POMC mRNA levels and decrease in NPY mRNA levels while aripiprazole may act as a negative control of metformin. Our results demonstrated that NPY mRNA levels were significantly decreased in both metformin administered and aripiprazole coadministered group, on the other hand, POMC mRNA levels were unexpectedly decreased in all groups.


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Although the use of atypical antipsychotic drugs is successful in the treatment of schizophrenia, they cause complications in the long term use that is mainly weight gain. In this study, circulating levels of hypothalamic neuropeptides/hormones, which are related to appetite regulation; neuropeptide Y (NPY), alpha melanocyte stimulating hormone (α-MSH), cocaine and amphethamine regulated transcript (CART) and plus leptin in male schizophrenic patients who were treated with an atypical antipsychotic drug, ri...
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The mechanism of weight gain due to treatment with olanzapine, a serotonin receptor antagonist, has not been fully understood. Weight gain and food intake are under the control of neuropeptides/hormones, POMC (proopiomelanocortin), CART (cocaine and amphetamine regulated transcript), AgRP (Agouti-related peptide) and NPY (neuropeptide Y) that are synthesized and secreted from the arcuate nucleus (ARC) of hypothalamus. In this study, the altereration of the ARC neuropeptide/hormone levels both in humans and ...
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Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can also be activated by factors present in circulating blood. Through application of high-content functional screening, we show that peripheral blood serum from first-onset drug-naive schizophrenia patients is suffici...
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Obsessive Compulsive Disorder (OCD) is a serious psychological disease that might be affiliated with abnormal resting-state functional connectivity (rs-FC) in default mode network (DMN) of brain. In this study it is aimed to discriminate patients with OCD from healthy individuals by employing pattern recognition methods on resting-state functional connectivity (rs-FC) data. For this purpose, two different feature extraction approaches were implemented. In the first approach the rs-FC fMRI data were subsampl...
Citation Formats
S. Özdemir, “Detection of hypothalamic neuropeptite levels involved in appetite regulation in aripiprazole treatment /,” M.S. - Master of Science, Middle East Technical University, 2014.