Detection of hypothalamic neuropeptite levels involved in appetite regulation in aripiprazole treatment /

Özdemir, Serhat
Disruption or malfunctioning of neurotransmitter pathways, especially serotonergic and dopaminergic pathways are closely related to psychotic disorders such as schizophrenia. Antipsychotic medications are becoming widespread; however, in long term treatments, these drugs lead to considerable amount of weight gain as a side effect. Metformin, an antidiabetic drug, has previously been used to treat antipsychotic induced weight gain and aripiprazole has been defined as a neutral antipsychotic drug in terms of weight gain. Yet, the underlying action mechanisms of these drugs are still inadequately understood. Hypothalamic neuropeptides releasing from arcuate nucleus (ARC) are known to be responsible for appetite and energy metabolism regulation. The aim of this study is to investigate the alteration of candidate gene expression levels of hypothalamic neuro peptides, neuropeptide Y (NPY) and proopiomelanocortin (POMC) by administration of metformin and aripiprazole to male Wistar rats for 14 weeks. We hypothesized that metformin may cause an increase in POMC mRNA levels and decrease in NPY mRNA levels while aripiprazole may act as a negative control of metformin. Our results demonstrated that NPY mRNA levels were significantly decreased in both metformin administered and aripiprazole coadministered group, on the other hand, POMC mRNA levels were unexpectedly decreased in all groups.


Alterations of hypothalamic neuropeptides involved in food intake and appetite in olanzapine monotherapy
Sezlev, Deniz; Yanık, Tülin; Department of Biology (2012)
The mechanism of weight gain due to treatment with olanzapine, a serotonin receptor antagonist, has not been fully understood. Weight gain and food intake are under the control of neuropeptides/hormones, POMC (proopiomelanocortin), CART (cocaine and amphetamine regulated transcript), AgRP (Agouti-related peptide) and NPY (neuropeptide Y) that are synthesized and secreted from the arcuate nucleus (ARC) of hypothalamus. In this study, the altereration of the ARC neuropeptide/hormone levels both in humans and ...
Determination of hypothalamic neuropeptide levels involved in appetite regulation in atypical antipsychotic drug, risperidone treatment
Kurşungöz, Canan; Yanık, Tülin; Department of Biology (2012)
Although the use of atypical antipsychotic drugs is successful in the treatment of schizophrenia, they cause complications in the long term use that is mainly weight gain. In this study, circulating levels of hypothalamic neuropeptides/hormones, which are related to appetite regulation; neuropeptide Y (NPY), alpha melanocyte stimulating hormone (α-MSH), cocaine and amphethamine regulated transcript (CART) and plus leptin in male schizophrenic patients who were treated with an atypical antipsychotic drug, ri...
The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Fusar-Poli, Laura; et. al. (2022-10-01)
Schizophrenia is frequently accompanied with social cognitive disturbances. Cannabis represents one established environmental factor associated with the onset and progression of schizophrenia. The present cross-sectional study aimed to investigate the association of facial emotion recognition (FER) performance with cannabis use in 2039 patients with schizophrenia, 2141 siblings, and 2049 healthy controls (HC). FER performance was measured using the Degraded Facial Affect Recognition Task (DFAR). Better FER ...
Evidence of microglial activation following exposure to serum from first-onset drug-naive schizophrenia patients
van Rees, Geertje Frederique; Lago, Santiago Guillermo; Cox, David Alan; Tomasik, Jakub; Rustogi, Nitin; Weigelt, Karin; Özcan Kabasakal, Süreyya; Cooper, Jason; Drexhage, Hemmo; Leweke, F. Markus; Bahn, Sabine (2018-01-01)
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can also be activated by factors present in circulating blood. Through application of high-content functional screening, we show that peripheral blood serum from first-onset drug-naive schizophrenia patients is suffici...
Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol
Yonar, Dilek; Sunnetcioglu, M. Maral (2016-06-01)
Cis-(Z)-flupentixol dihydrochloride (FLU), a thioxanthene drug, is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders. Since the action mechanism of FLU is not completely understood, the main objective of present study is to provide a detailed evaluation of flupentixol-phospholipid membrane interactions at molecular level. FLU-dipalmitoylphosphatidylcholine (DPPC) interactions in presence and absence of cholesterol (CHO) were investigated as a function of temperature. The cha...
Citation Formats
S. Özdemir, “Detection of hypothalamic neuropeptite levels involved in appetite regulation in aripiprazole treatment /,” M.S. - Master of Science, Middle East Technical University, 2014.