AN ANALYSIS OF NMDA AND BETA-ADRENERGIC RECEPTOR ANTAGONISTS ADMINISTRATION AND NEURAL C-FOS EXPRESSION FOLLOWING CONDITIONED CONTEXT AVERSION LEARNING IN MICE

Download

10533887.pdf

Date

2023-3-17

Author

İlhan, Furkan

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

210
views

58
downloads

Cancer patients develop anticipatory nausea and vomiting (ANV) following chemotherapy treatment as a result of classical conditioning learning. Although researchers have been conducting clinical studies to understand the characteristics of ANV, animal models can also be utilized to develop novel diagnostics and therapeutics. Conditioned context aversion (CCA) has been accepted to arise from classical conditioning and used as an animal model of ANV. Although antiemetic agents were widely used to prevent nausea and vomiting, 25% of cancer patients still develop ANV. However, the formation of memories can be prevented during consolidation phase of memory formation. We conducted two experiments (Experiment 1 and Experiment 2) to investigate memory impairing effect of N-methyl-D-aspartate antagonist MK-801 and beta-adrenergic antagonist propranolol on CCA. We found that systemic administration of propranolol but not MK-801 prevented animals from developing CCA. v Although behavioral research mainly established the principles of CCA learning, it’s neural substrate is yet to be investigated. Experiment 3 was conducted to identify the brain regions involved in CCA learning. We found elevated c-Fos expression in the prelimbic division of the medial prefrontal cortex, IC, basolateral nucleus of the amygdala, CA1-CA2 and dentate gyrus subregions of the hippocampus, indicating that these brain regions are activated following CCA. To the best of our knowledge, ours is the first study finding memory impairments induced by beta-adrenergic receptor antagonist in CCA and showing neural correlates of CCA learning. Further research is necessary to unravel causal involvement of these brain regions in the development of CCA.

Subject Keywords

anticipatory nausea and nausea, cancer, conditioning, learning, mice

URI

https://hdl.handle.net/11511/102573

Collections

Graduate School of Social Sciences, Thesis

Suggestions

OpenMETU
Core

Multiscale tumor modeling Ünsal, Serbülent; Acar, Aybar Can; Department of Health Informatics (2014) Cancer’s complex behavior decreases success rates of the cancer therapies. The usual steps cancer therapy are, deciding phase of the cancer and planing the therapy according to medical guidelines and there is no room or chance for personalized medicine. Simulation systems that use patient specific data as input and up-to-date scientific evidence as business rules has chance to help clinicians for evidence based personalized medicine practice.In this study our aim is creating a basic model to guide researche...
Investigaton of chemopreventive properties of Urtica Dioica L., in MCF-7 and MDA231 breast cancer cell lines Güler, Elif; İşcan, Mesude; Department of Biology (2011) Cancer is a major health problem in developing world with mostly unsufficient treatment. Cancer prevention through dietary modification appears to be a practical and cost effective possibility. The aim of present study is to investigate the chemical components of “Urtica diocia,L (U. diocia) grown in Turkey” and the possible protective potential of its aqueous extract against breast cancer cell lines. U. diocia was extracted by maceration method which was performed for 6,12, 24, and 36 hours, at 50°C, 37°C,...
Examination of the coping processes of caregivers of children with cancer Demirtepe Saygılı, Dilek; Bozo Özen, Özlem; Department of Psychology (2013) The general aim of the present dissertation was to examine the coping processes of the caregivers of children with cancer. It was composed of three studies, whose aims were (1) to reveal the predictors of caregiver distress by using the Transactional Theory of Coping among the caregivers of children with cancer; (2) to identify the factors associated with caregiving process from the caregiver’s perspective qualitatively; (3) to develop and implement an intervention program. Study 1 was conducted with 105 pa...
GST isoenzymes in matched normal and neoplastic breast tissue OĞUZTÜZÜN, SERPİL; Abu-Hijleh, A.; ÇOBAN, TÜLAY; Bulbul, D.; KILIÇ, MURAT; İŞCAN, Mümtaz; İşcan, Mesude (AEPress, s.r.o., 2011-01-01) The potential to metabolize endogenous and exogenous substances may influence breast cancer development and tumor growth. Therefore we investigated GST activity and the protein expression of glutathione S-transferases (GSTs) isoenzymes known to be involved in the metabolism of endogenous and exogenous carcinogens in breast cancer tissue to obtain new information on their possible role in tumor progression.
Development and characterization of cortisone derivative drugcarrying polymeric microspheres Öcal, Yiğit; Keskin, Dilek; Özen, Seza; Department of Biomedical Engineering (2011) In this study, it is aimed to develop an injectable controlled release system of PCL and P(L,DL)LA microspheres loaded with TA and/or Ral for local treatment of rheumatoid arthritis which will avoid from systemic side effects of traditional administration and eliminate problems caused by direct local injections. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder that most commonly causes inflammation and tissue damage in joints and tendon sheaths. Current strategies for the disease are ma...

Citation Formats

F. İlhan, “AN ANALYSIS OF NMDA AND BETA-ADRENERGIC RECEPTOR ANTAGONISTS ADMINISTRATION AND NEURAL C-FOS EXPRESSION FOLLOWING CONDITIONED CONTEXT AVERSION LEARNING IN MICE,” M.S. - Master of Science, Middle East Technical University, 2023.