Efficient synthesis of novel near ir emitting distyrylboradiazaindacene sensitizers for photodynamic therapy

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2006

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Dost, Zeynep

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Photodynamic therapy (PDT) is a noninvasive method of treating malignant tumors and age-related macular degeneration. Current practice of PDT is limited to a few functionalized porphyrins, however these compounds are not considered to be ideal drugs for use in PDT. Among the limitations, the most prominent is the low extinction coefficient of porphyrins in the body’s therapeutic window. Therefore, there is a significant impetus to develop novel and better efficiency sensitizers for use in PDT. Boradiazaindacenes (BODIPY dyes or difluoroboradipyrrines) are well known fluorescent dyes. We discovered novel distyryl-derivatized boradiazaindacene dyes. These dyes have strong absorptions beyond 650nm. In order to transform these novel dyes into potential PDT reagents, bromine substituents were placed and then heavy atom effect was showed. We also demonstrated that on red-light excitation, singlet oxygen trap 1,3-diphenyl-iso-benzofuran is rapidly degraded.

Subject Keywords

Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/2/12607377/index.pdf
https://hdl.handle.net/11511/16179

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

Z. Dost, “Efficient synthesis of novel near ir emitting distyrylboradiazaindacene sensitizers for photodynamic therapy,” M.S. - Master of Science, Middle East Technical University, 2006.