Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy

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2006

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Atılgan, Serdar

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Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease classes, both cancerous and noncancerous. This has brought about an active pursiut of new PDT agents that can be optimized for the unique set of photophysical characteristics that are required for a succesful clinical agent. There are many reported or commercially available photosensitizers, but most have limitations, such as low photostability, or a limited usable range of solvent conditions. In this study, we introduced a novel class of extended conjugation water soluble boradiazaindacene dyes which are efficient singlet oxygen generators. These sensitizers have strong absorptions in the therapeutic window and have spectacular photoinduced cytotoxicity. In addition, they display no dark toxicity at the active concentrations. With these remarkable properties, they are likely to find applications as promising new reagents for photodynamic therapy.

Subject Keywords

Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/12607601/index.pdf
https://hdl.handle.net/11511/16290

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

S. Atılgan, “Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy,” M.S. - Master of Science, Middle East Technical University, 2006.