Synthesis and reactions of alpha-keto-beta-hydroxyphosphonates

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2007
Barış, Şehriban
This thesis presents synthesis and different reactions of alpha-keto-beta-hydroxyphosphonates. Toward this aim, the hydroxyl functionality of alpha-hydroxycarboxylic acids were protected with alkyl or acyl groups and then formation of acid chloride followed by the reaction with trialkylphosphite furnished protected alpha-keto-beta-hydroxyphosponates. Nucleophilic addition reactions were applied to these compounds to obtain quaternary alcohols with phosphonate functionality. The addition reactions were tried with organocatalysts for the enantioselective formation of desired products.

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Citation Formats
Ş. Barış, “Synthesis and reactions of alpha-keto-beta-hydroxyphosphonates,” M.S. - Master of Science, Middle East Technical University, 2007.