Synthesis and reactions of alpha-keto-beta-hydroxyphosphonates

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2007

Author

Barış, Şehriban

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This thesis presents synthesis and different reactions of alpha-keto-beta-hydroxyphosphonates. Toward this aim, the hydroxyl functionality of alpha-hydroxycarboxylic acids were protected with alkyl or acyl groups and then formation of acid chloride followed by the reaction with trialkylphosphite furnished protected alpha-keto-beta-hydroxyphosponates. Nucleophilic addition reactions were applied to these compounds to obtain quaternary alcohols with phosphonate functionality. The addition reactions were tried with organocatalysts for the enantioselective formation of desired products.

Subject Keywords

Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/3/12608215/index.pdf
https://hdl.handle.net/11511/16681

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

Ş. Barış, “Synthesis and reactions of alpha-keto-beta-hydroxyphosphonates,” M.S. - Master of Science, Middle East Technical University, 2007.