Investigations on the biodegradable polymeric and inorganic substrates for controlled drug delivery and bone and cartilage repair

Download

index.pdf

Date

2008

Author

Günay, Aycan

Metadata

Show full item record

Item Usage Stats

260
views

80
downloads

Tissue engineering is an interdisciplinary field that seeks to address the needs by applying the principles of chemistry, biology and engineering for the development of viable substitutes that restore and maintain the function of human bone and cartilage tissues. In tissue engineering, scaffolds play an important role as temporary supports for the transplantation of specific cells and tissues. In this study, poly(ester-urethane)urea (PEUU) and poly(caprolactone) (PCL) scaffolds were fabricated. Scaffolds were characterized by SEM. Porosities of scaffolds vary from 67 % to 80 %. Controlled drug delivery systems release drugs at predetermined rates for extended periods. In this study; firstly poly(lactic-co-glycolicolide/tricalcium phosphate) (PLGA/TCP) and poly(L-lactide)/tricalcium phosphate (PLLA/TCP) composites loaded with Gentamicin or Vancomycin were prepared as controlled drug delivery systems for the local treatment of osteomyelitis. The release behavior of drugs were monitored by UV-VIS spectrometer. It was shown that, Vancomycin loaded samples released higher amounts of drug than the samples loaded with Gentamicin. Secondly, porous ceramic samples were coated with PLGA and PLLA and they were loaded with dexamethasone. The release behavior of samples were monitored by UV-VIS spectrometer.The cubic ceramics released higher amounts of dexamethasone than cylindrical ceramics. When the mechanical properties of porous ceramic samples were concerned, PLLA coated samples had better mechanical properties.

Subject Keywords

Polymers.

URI

http://etd.lib.metu.edu.tr/upload/12609303/index.pdf
https://hdl.handle.net/11511/17522

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Development and analysis of controlled release polymeric rods containing vancomycin Tağıt, Oya; Hasırcı, Vasıf Nejat; Department of Biotechnology (2005) Antibiotic use is a vital method for the treatment of most diseases involving bacterial infections. Unfortunately, in certain cases these agents are not effective in treatments against diseases for either some limitation in antibiotic usage because of the side effects or some distribution problems caused by physiological or pathological barriers in the body. Such problems are thought to be minimized by development of controlled release systems which involve implantation of antibiotic loaded polymeric system...
Pyrolysis mass spectrometric analysis of copolymer of polyacrylonitrile and polythiophene Oğuz, Gülcan; Hacaloğlu, Jale; Department of Polymer Science and Technology (2004) In the first part of this work, the structural and thermal characteristics of polyacrylonitrile, polyacrylonitrile films treated under the electrolysis conditions in the absence of thiophene, polythiophene and the mechanical mixture and a conducting copolymer of polyacrylonitrile/polythiophene have been studied by pyrolysis mass spectrometry technique. The thermal degradation of polyacrylonitrile occurs in three steps; evolution of HCN, monomer, low molecular weight oligomers due to random chain cleavages a...
Preparation and characterization of acrylic bone cements Endoğan, Tuğba; Hasırcı, Nesrin; Department of Chemistry (2005) Acrylic bone cements are used in dentistry and orthopedic surgery to fix prosthetic devices into the bone. Bone cements transfer and distribute the applied load and increase the load-carrying capacity of the prosthesis/cement/bone system with the help of mechanical bonding between the device and the bone. In spite of all their advantages, bone cements have several drawbacks such as insufficient mechanical properties, high exothermic polymerization temperature, release of monomer to the environmental tissue ...
Development of a novel functionally graded membrane containing boron-modified bioactive glass nanoparticles for guided bone regeneration Rad, Reza Moonesi; Atila, Deniz; Evis, Zafer; Keskin, Dilek; Tezcaner, Ayşen (2019-08-01) Barrier membranes are used in periodontal tissue engineering for successful neo-bone tissue formation and prevention of bacterial colonization. We aimed to prepare and characterize novel 7% boron-modified bioactive glass (7B-BG) containing bilayered membrane for this end. We hypothesized that presence of 7B-BG could promote structural and biological properties of guided bone regeneration (GBR) membrane. Cellulose acetate (CA) layer was prepared by solvent casting, and functionally graded layer of CA/gelatin...
Synthesis of conducting block copolymers and their use in the immobilization of invertase and polyphenol oxidase enzyme Kıralp, Senem; Kıralp, Senem; Department of Chemistry (2004) A new thiophene derivative containing menthyl group (MM) was synthesized and polymerized via chemical and electrochemical methods. Polymers obtained and MM itself were used to synthesize copolymers with pyrrole under conditions of constant potential electrolysis. Cyclic Voltammetry, thermal analysis and scanning electron microscopy analyses were performed for the characterization of samples. Immobilization of invertase and polyphenol oxidase enzymes was performed in the matrices obtained via copolymerizatio...

Citation Formats

A. Günay, “Investigations on the biodegradable polymeric and inorganic substrates for controlled drug delivery and bone and cartilage repair,” M.S. - Master of Science, Middle East Technical University, 2008.