Preparation and characterization of acrylic bone cements

Endoğan, Tuğba
Acrylic bone cements are used in dentistry and orthopedic surgery to fix prosthetic devices into the bone. Bone cements transfer and distribute the applied load and increase the load-carrying capacity of the prosthesis/cement/bone system with the help of mechanical bonding between the device and the bone. In spite of all their advantages, bone cements have several drawbacks such as insufficient mechanical properties, high exothermic polymerization temperature, release of monomer to the environmental tissue and loosening of implant. Studies are being carried out to improve bone cement formulations with low curing temperature, good mechanical properties and good biocompatibility. In this study, bone cements with different compositions were prepared by using poly(methyl methacrylate) (PMMA) microspheres, barium sulphate (BaSO4) radiopaque agent, inorganic hydroxyapatite (HA) particles and 1-dodecyl mercaptan (DDM) chain stopping agent. Mechanical and thermal properties of the prepared bone cements were examined. When 8% hydroxyapatite was added into the formulation, both tensile and compressive strengths were increased and curing temperature was decreased. Addition of 13% BaSO4 caused 0.98% and 10.29% decrease in tensile and compressive strength values, respectively. Addition of 1%, 2% and 3% DDM, relative to the amount of methyl methacrylate monomer, decreased the maximum temperature from 101.78°C to 91.80°C, 78.38°C and 71.35°C, respectively. All compositions of the prepared bone cements fulfilled the minimum compressive strength (70 MPa) requirement and the minimum curing temperature was obtained as 71.35°C. In order to have optimum desired properties, further studies to improve biocompatibility, mechanical and thermal properties of bone cements are needed.


Preparation and Characterization of Chitosan Containing Acrylic Bone Cement Formulations
Endogan, Tugba; Kızıltay, Aysel; Hasırcı, Nesrin (2009-05-22)
Bone cements are used in orthopaedic surgery and dentistry, and the commonly used commercial ones are prepared from poly (methylmethacrylate) (PMMA). In orthopaedic surgery bone cements are used as filling agents for the treatment of damaged tissues and they are used to stabilize the prosthesis by providing the mechanical interlock between bone and metal during the use of metal prothesis and to provide the homogeneous distribution of applied load. In this study, bone cements compositions were prepared by us...
Preparation and characterization of hydroxyapatite containing acrylic bone cements
Başgörenay, Burcu; Hasırcı, Nesrin; Department of Polymer Science and Technology (2004)
Acrylic bone cements are one of the most important biomaterials used in orthopaedic surgery and dental applications to fill the cavities or provide mechanical interlock between prosthesis and the bone. Their biocompatibility can be increased by addition of different materials into the formulation, such as hydroxyapatite. Besides all the advantages, bone cements have several drawbacks including tissue necrosis, chemical necrosis, shrinkage of the cement and aseptic loosening. Therefore painstaking research a...
Investigations on the biodegradable polymeric and inorganic substrates for controlled drug delivery and bone and cartilage repair
Günay, Aycan; Bayramlı, Erdal; Department of Polymer Science and Technology (2008)
Tissue engineering is an interdisciplinary field that seeks to address the needs by applying the principles of chemistry, biology and engineering for the development of viable substitutes that restore and maintain the function of human bone and cartilage tissues. In tissue engineering, scaffolds play an important role as temporary supports for the transplantation of specific cells and tissues. In this study, poly(ester-urethane)urea (PEUU) and poly(caprolactone) (PCL) scaffolds were fabricated. Scaffolds we...
Bacterial cellulose-reinforced boron-doped hydroxyapatite/gelatin scaffolds for bone tissue engineering
Atila, Deniz; Karataş, Ayten; Evcin, Atilla; Keskin, Dilek; Tezcaner, Ayşen (Springer Science and Business Media LLC, 2019-12-01)
Today, many people are suffering from bone defects due to trauma, tumor or bone related diseases. Mimicking bone in terms of composition and structure has been a challenge for tissue engineers. In this study, a novel 3D porous tissue-engineered construct composed of natural and easily-accessible biomaterials, namely (1) an exopolysaccharide; bacterial cellulose (BC), (2) mineral crystals; boron-doped nano-hydroxyapatite (BHA), and (3) a natural protein; gelatin (GEL) as the main constituting biomaterial was...
Biodegradable polymer - hydroxyapatite nanocomposites for bone plate applıcations
Aydın, Erkin; Hasırcı, Vasıf Nejat; Planell, Joseph A.; Department of Biotechnology (2010)
Long bone fractures are fixed with bone plates to restrain movement of bone fragments. Fracture site must experience some pressure for proper healing. Bone plates are mostly made up of metals having 5 - 10 times higher elastic modulus than bones and most of the load is carried by them, leading to stress shielding and a bony tissue with low mineral density and strength. To avoid these problems, biodegradable polymer-based composite plates were designed and tested in this study. Poly(L-lactide) and Poly(3-hyd...
Citation Formats
T. Endoğan, “Preparation and characterization of acrylic bone cements,” M.S. - Master of Science, Middle East Technical University, 2005.