Vancomycin containing plla delivery system for bone tissue biocompatibility and treatment of implant related chronic osteomyelitis

Uysal, Berna
Osteomyelitis is an infection of bone or bone marrow, usually caused by pyogenic bacteria. It can cultivate by hematogen way or it can cultivate by the help of local soft tissue infection. Osteomyelitis often requires prolonged antibiotic therapy and surgery. But for therapy; antibiotic must reach to effective dose in the bone. So that; for prevention and treatment of osteomyelitis controlled antibiotic release systems can be used. These systems have been developed to deliver antibiotics directly to infected tissue. As a carrier material; polymers are widely use. Polymer can be biodegradable or non biodegradable. The advantage of biodegradable polymers is; you do not need a second surgery for the removal of the carrier material from the body. In this study; vancomycin loaded PLLA/TCP composites were developed and characterized to treat implant related chronic osteomyelitis in experimental rat osteomyelitis model. Some of the composites were prepared by coating the vancomycin loaded composites with PLLA to observe the difference between the coated and uncoated composites. Also, some composites were developed free from the vancomycin to determine the biocompatibility of the composite for the bone tissue. The coating extended the release of the vancomycin up to 5 weeks and changed the surface morphology of the composites. According to the cell culture studies, vancomycin loaded PLLA/TCP composites promoted cell adhesion, cell proliferation and mineralization so; the composite was biocompatible with bone tissue. Radiological and microbiological evaluations showed that vancomycin loaded and coated vancomycin loaded PLLA/TCP composites inhibited MRSA proliferation and treat implant related chronic osteomyelitis.


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Citation Formats
B. Uysal, “Vancomycin containing plla delivery system for bone tissue biocompatibility and treatment of implant related chronic osteomyelitis,” M.S. - Master of Science, Middle East Technical University, 2009.