Synthesis of linkers and mediators for electrochemical reactor design and enantiopure synthon preparation

Download

index.pdf

Date

2009

Author

Akbaşoğlu, Naime

Metadata

Show full item record

Item Usage Stats

209
views

73
downloads

The thesis subject is mainly involved in Green Chemistry approach. Thiophene, furan and pyridine carboxaldehydes were chosen as starting compounds and vinylation and allylation with Grignard reaction afforded the corresponding racemic heteroaryl substituted allylic and homoallylic alcohols. Subsequent resolution with enzymes (PS-Amano II, Lipozym and Novazym 435) gave enantiomerically enriched alcohols with the e.e. values varied between 65 and 99%. The absolute configurations of all substrates are known. As a result of O-allylation with the common procedure formed the feasible carbon backbone for the ring closing metathesis reaction. All ring closing metathesis reactions were performed by Grubbs’ catalyst with just 5% catalyst loading. The absolute configurations of dihydrofuran and dihydropyran derivatives are known, since the chiral center configurations of all substrates are preserved throughout all the applied processes.

Subject Keywords

Chemistry., Chemistry, Organic

URI

http://etd.lib.metu.edu.tr/upload/12610930/index.pdf
https://hdl.handle.net/11511/19067

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Synthesis of heteroaryl substituted dihydrofuran and dihydropyran derivatives by green chemistry approach Demirci, Sema; Tanyeli, Cihangir; Department of Chemistry (2009) The thesis subject is mainly involved in Green Chemistry approach. Thiophene, furan and pyridine carboxaldehydes were chosen as starting compounds and vinylation and allylation with Grignard reaction afforded the corresponding racemic heteroaryl substituted allylic and homoallylic alcohols. Subsequent resolution with enzymes (PS-Amano II, Lipozym and Novazym 435) gave enantiomerically enriched alcohols with the e.e. values varied between 65 and 99%. The absolute configurations of all substrates are known. A...
Phenylethynyl-bodipy oligomers: bright dyes and fluorescent building blocks Çakmak, Yusuf; Akkaya, Engin Umut; Department of Chemistry (2008) Supramolecular chemistry is an emerging field of chemistry which has attracted much attention in recent years as a result of its broad applicability in many areas. Thus, the design of functional supramolecular systems is strongly in demand in this field. For this purpose, we have developed novel phenylethynyl-BODIPY oligomer series which have absorption and emission maxima at the red part of the visible region of electromagnetic spectrum. Careful design to assemble the decyl groups to the system allowed us ...
Rational design of ratiometric chemosensor via modulation of energy donor efficiency Guliyev, Ruslan; Akkaya, Engin Umut; Department of Chemistry (2008) Rational design of fluorescent chemosensors is an active area of supramolecular chemistry, photochemistry and photophysics. Ratiometric chemosensors are even more important, as they have an internal system for selfcalibration. In order to develop a new methodology for a ratiometric chemosensor design, we proposed coupling of energy transfer phenomenon to ion sensing. In this study, we targeted energy transfer cassette type chemosensors, where the efficiency of transfer is modulated on the donor side, by met...
Synthesis and enzymatic resolution of various cyclopentenoid and cyclohexenoid type compounds İyigün, Çiğdem; Tanyeli, Cihangir; Department of Chemistry (2005) The aim of this thesis is to synthesize enantiomerically enriched cyclopentenoid and cyclohexenoid type of compounds with quaternary carbon stereocenters that are the simplest precursors of the complex natural products. The first part of the study involves the preparation of ?'-acetoxy ?'-substituted ?,β-unsaturated cyclic ketones. Methylation, ethylation, benzylation and allylation of cyclohexenone and cyclopentenone derivatives are performed. Then, these compounds are regioselectively oxidized at the ?'-p...
Structural analysis of polyaniline-polyprrole copolmers via pyrolysis mass spectrometry Tezal, Feride; Küçükyavuz, Zuhal; Department of Chemistry (2007) This thesis describes recent progress in electrochemical preparation of several conducting polymers. In particular, the synthesis and characterizations of pure polyaniline, pure polypyrrole, polyaniline/polypyrrole and polypyrrole/polyaniline copolymers and polyaniline-polypyrrole physical blends were studied. The focus has included firstly synthesis of these electrically conductive polymers. Secondly, thermal characteristics of electrochemically synthesized homopoly- mers, copolymers and their physical ble...

Citation Formats

N. Akbaşoğlu, “Synthesis of linkers and mediators for electrochemical reactor design and enantiopure synthon preparation,” M.S. - Master of Science, Middle East Technical University, 2009.