Rational design of ratiometric chemosensor via modulation of energy donor efficiency

Download

index.pdf

Date

2008

Author

Guliyev, Ruslan

Metadata

Show full item record

Item Usage Stats

233
views

95
downloads

Rational design of fluorescent chemosensors is an active area of supramolecular chemistry, photochemistry and photophysics. Ratiometric chemosensors are even more important, as they have an internal system for selfcalibration. In order to develop a new methodology for a ratiometric chemosensor design, we proposed coupling of energy transfer phenomenon to ion sensing. In this study, we targeted energy transfer cassette type chemosensors, where the efficiency of transfer is modulated on the donor side, by metal ion binding which changes the spectral overlap. This work involves the synthesis of a number of EET systems with varying degrees of EET efficiency. The results suggest that this strategy for ratiometric ion sensing is a promising one, enabling a modular approach in chemosensor design.

Subject Keywords

Chemistry., Chemistry, Organic

URI

http://etd.lib.metu.edu.tr/upload/12609889/index.pdf
https://hdl.handle.net/11511/18226

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Novel studies on the chemoenzymatic synthesis of polychlorinated bicyclic systems and the synthesis of C2 and C3 symmetric chiral ligands Türkmen, Yunus Emre; Tanyeli, Cihangir; Department of Chemistry (2006) Optically active polychlorinated bicyclic systems are important starting materials for the synthesis of complex target molecules. In the first part of the study, the syntheses of several racemic and meso hexachloronorbornene derivatives were executed successfully, starting from hexachlorocyclopentadiene. The enantio-enriched acetoxymethyl derivative (-)-2 and the hemiester (-)-6 were synthesized in high e.e. values by using several hydrolase type enzymes. The absolute configuration of (-)-2 was determined b...
Phenylethynyl-bodipy oligomers: bright dyes and fluorescent building blocks Çakmak, Yusuf; Akkaya, Engin Umut; Department of Chemistry (2008) Supramolecular chemistry is an emerging field of chemistry which has attracted much attention in recent years as a result of its broad applicability in many areas. Thus, the design of functional supramolecular systems is strongly in demand in this field. For this purpose, we have developed novel phenylethynyl-BODIPY oligomer series which have absorption and emission maxima at the red part of the visible region of electromagnetic spectrum. Careful design to assemble the decyl groups to the system allowed us ...
Synthesis of linkers and mediators for electrochemical reactor design and enantiopure synthon preparation Akbaşoğlu, Naime; Demir, Ayhan Sıtkı; Department of Chemistry (2009) The thesis subject is mainly involved in Green Chemistry approach. Thiophene, furan and pyridine carboxaldehydes were chosen as starting compounds and vinylation and allylation with Grignard reaction afforded the corresponding racemic heteroaryl substituted allylic and homoallylic alcohols. Subsequent resolution with enzymes (PS-Amano II, Lipozym and Novazym 435) gave enantiomerically enriched alcohols with the e.e. values varied between 65 and 99%. The absolute configurations of all substrates are known. A...
Extraordinary Modes of Bonding Enabled by the Triquinane Framework Günbaş, Emrullah Görkem (American Chemical Society (ACS), 2013-10-04) Incorporation of triquinane ring systems into a macrobicyclic framework enables the stabilization of unusual bonding arrangements, including 3-center-2-electron cation, 3-center-3-electron radical, and 3-center-4-electron anion systems, linear divalent fluorine, triplet carbenes, record short C-C bonds, a powerful proton sponge effect, and oxadionium (R4O2+) ions. The means to stabilize and conceivably isolate such species derives from the rigid, convex nature of the triquinane ring system, as well as the s...
Chemoenzymatic synthesis of chiral hydroxymethyl cycloalkenols Şenocak, Deniz; Demir, Ayhan Sıtkı; Department of Chemistry (2004) Chiral cyclic alkenols with hydroxymethyl functionality are important structural units in many biologically active natural compouds such as prostaglandins, sesquiterpene antiviral agents, pentenomycins, xanthocidin, sarkomycin, etc. 1,3-cycloalkanediones are converted into bicyclic polyoxo derivatives with formaldehyde and trioxane in the presence of Lewis acid. Selective oxidation of the bicyclic compounds by using manganese(III)acetate followed by enzyme-catalyzed kinetic resolution afforded chiral bicycl...

Citation Formats

R. Guliyev, “Rational design of ratiometric chemosensor via modulation of energy donor efficiency,” M.S. - Master of Science, Middle East Technical University, 2008.