Synthesis of bishomo-inositol derivatives

Download

index.pdf

Date

2011

Author

Bekarlar, Merve Gökçen

Metadata

Show full item record

Item Usage Stats

161
views

62
downloads

Inositols belong to an important class of biologically active compounds, named as cyclitols (cyclic polyols), which have attributed high interest in the past decade due to the glycosidase inhbition property that affects many biological processes. Initially, 1,3,3a,7a-tetrahydro-2-benzofuran (69) was synthesized as a key compound to synthesize bishomo-inositol derivatives. Then photooxygenation and manganese(III) acetate oxidation reactions of this key compound were studied in order to obtain isomeric inositol derivatives. Moreover, dihydroxylation and acid catalyzed ring opening reactions were investigated. Finally, new synthetic approaches for the synthesis of bishomo-inositol derivatives have been developed. In addition to that whole products were conscientiously purified and characterized and mechanism for the formation of the products has been discussed.

Subject Keywords

Derivatives (Chemicals), Chemistry, Organic.

URI

http://etd.lib.metu.edu.tr/upload/12613735/index.pdf
https://hdl.handle.net/11511/21259

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Inorganic antimony speciation using tungsten coil atom trap and hydride generation atomic absorption spectrometry Akay, Pınar; Ataman, Osman Yavuz; Department of Chemistry (2010) Antimony is a toxic element which is mostly found in two oxidation states (III and V) in environmental, biological and geological samples. Antimony may form various inorganic and organic compounds that exhibit differences in analytical behavior, toxicity and mobility; inorganic compounds of antimony are more toxic than organic forms and toxicity of Sb(III) has been shown to be 10 times higher than that of Sb(V). Therefore selective determination of Sb(III) and Sb(V) is required in environmental and biologic...
Synthesis of ferrocenyl substituted quinolines Velioğlu, Özlem; Zora, Metin; Department of Chemistry (2008) Quinolines have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of quinolines with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigat...
SYNTHESIS OF 2,3-DITHIOFENIL DERIVATIVES OF PYRROL ON THE BASIS OF 2,2 '-THIONINE Maharramov, A. M.; Akay, P.; Akhmedov, I. M.; Safarova, A. S.; Qurbanova, M. M.; Huseynov, E. Z.; Musayeva, S. A. (2019-01-01) It is known that pyrrole and its derivatives are a part of many important natural compounds. Polymeric semiconductors also were obtained on the basis of 2,5-dithienyl-pyrrole electropolymerization and its derivatives. The work deals with the synthesis of 2,3-dithiophenyl-1H-pyrroles by the reaction of 2,2'-thionine with various enamines.
Development of new synthetic methodologies for indole derivatives Kılıklı, Ahmet Alper; Balcı, Metin; Department of Chemistry (2010) Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besi...
Synthesis of ferrocenyl cycloheptadienones Açıkgöz, Canet; Zora, Metin; Department of Chemistry (2005) Synthesis of seven-membered ring systems such as cycloheptadienones has attracted a great deal of attention in organic chemistry since they are present in a variety of biologically important molecules. Incorporation of the essential structures of such compounds with a ferrocene moiety instead of an aryl group could provide subtances with enhanced antitumor activities since some ferrocene derivatives have already proved to be active against a number of tumors. To develop a ferrocenyl-substituted seven-member...

Citation Formats

M. G. Bekarlar, “Synthesis of bishomo-inositol derivatives,” M.S. - Master of Science, Middle East Technical University, 2011.