Investigation of fluid structure interaction in cardiovascular system from diagnostic and pathological perspective

Salman, Hüseyin Enes
Atherosclerosis is a disease of the cardiovascular system where a stenosis may develop in an artery which is an abnormal narrowing in the blood vessel that adversely affects the blood flow. Due to the constriction of the blood vessel, the flow is disturbed, forming a jet and recirculation downstream of the stenosis. Dynamic pressure fluctuations on the inner wall of the blood vessel leads to the vibration of the vessel structure and acoustic energy is propagated through the surrounding tissue that can be detected on the skin surface. Acoustic energy radiating from the interaction of blood flow and stenotic blood vessel carries valuable information from a diagnostic perspective. In this study, a constricted blood flow is modeled by using ADINA finite element analysis software together with the blood vessel in the form of a thin cylindrical shell with an idealized blunt constriction. The flow is considered as incompressible and Newtonian. Water properties at indoor temperature are used for the fluid model. The diameter of the modeled vessel is 6.4 mm with 87% area reduction at the throat of the stenosis. The flow is investigated for Reynolds numbers 1000 and 2000. The problem is handled in three parts which are rigid wall Computational Fluid Dynamics (CFD) solution, structural analysis of fluid filled cylindrical shell, and Fluid Structure Interaction (FSI) solutions of fluid flow and vessel structure. The pressure fluctuations and consequential vessel wall vibrations display broadband spectral content over a range of several hundred Hz with strong fluid-structural coupling. Maximum dynamic pressure and vibration amplitudes are observed around the reattachment point of the flow near the exit of the stenosis and this effect gradually decreases along downstream of flow. Results obtained by the numerical simulations are compared with relevant studies in the literature and it is concluded that ADINA can be used to investigate these types of problems involving high frequency pressure fluctuations of the fluid and the resulting vibratory motion of the surrounding blood vessel structure.


Non-invasive acoustic detection of vascular diseases from skin surface using computational techniques with fluid-structure interaction
Salman, Hüseyin Enes; Yazıcıoğlu, Yiğit; Ciğeroğlu, Ender; Department of Mechanical Engineering (2018)
Atherosclerosis is a cardiovascular disease in which arterial occlusion adversely affects blood circulation. Because of the narrowing of the artery, the blood flow is disturbed and a recirculating flow occurs at the downstream of the stenosis exit. The dynamic pressure fluctuations on the inner arterial wall cause the blood vessel wall to vibrate and the resulting acoustic energy propagates through the surrounding soft tissue and reaches the skin surface. To understand the problem in more detail, computatio...
Numerical Study on Blood Flow Modelling in Arteries
Kaya Merdan, Songül (null; 2018-06-29)
In order to prevent, diagnose and treat vascular disease, detailed knowledge of blood blow and the response of blood vessels is essential. The use of computer simulations can provide researchers extremely useful tool of the interpretation and analysis of the circulatory sysytem in both physiological and pathological situations. In this work, we present a 2D mathematical model to forecast for some cardivascular diseases such as stenosis and aneurysms geometry. We consider a blood flow based on Stokes and Nav...
Investigation of on skin surface response due to acoustic radiation from stenosed blood vessels
Salman, Huseyin E.; Yazıcıoğlu, Yiğit (2015-11-02)
Arterial stenosis is a form of cardiovascular disease which leads to highest rate of fatalities worldwide. When stenosis is present in coronary arteries, it leads to heart attack and often sudden death. Arterial disease is usually not confined to critical organs such as the heart and the brain but observed throughout the peripheral cardiovascular system. When an artery has a diameter reduction, acoustic radiation originating from this constriction propagates through soft tissues and reaches to skin surface....
Flow-induced vibration analysis of constricted artery models with surrounding soft tissue
Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (2017-10-01)
Arterial stenosis is a vascular pathology which leads to serious cardiovascular diseases. Blood flow through a constriction generates sound and vibration due to fluctuating turbulent pressures. Generated vibro-acoustic waves propagate through surrounding soft tissues and reach the skin surface and may provide valuable insight for noninvasive diagnostic purposes. Motivated by the aforementioned phenomena, vibration of constricted arteries is investigated employing computational models. The flow-induced press...
Computational analysis for non-invasive detection of stenosis in peripheral arteries
Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Elsevier BV, 2019-08-01)
Atherosclerosis usually affects the entire cardiovascular system, including peripheral blood vessels. Peripheral arterial stenosis may indicate possible serious vascular disorders related to more vital organs. If peripheral arterial stenosis can be discerned at an early stage, it can serve as a warning sign to take precautions, such as using more invasive diagnostic techniques or adopting a healthier life style. In this study, peripheral regions, such as the thigh, upper arm, and neck are modelled consideri...
Citation Formats
H. E. Salman, “Investigation of fluid structure interaction in cardiovascular system from diagnostic and pathological perspective,” M.S. - Master of Science, Middle East Technical University, 2012.