Investigation of on skin surface response due to acoustic radiation from stenosed blood vessels

Salman, Huseyin E.
Yazıcıoğlu, Yiğit
Arterial stenosis is a form of cardiovascular disease which leads to highest rate of fatalities worldwide. When stenosis is present in coronary arteries, it leads to heart attack and often sudden death. Arterial disease is usually not confined to critical organs such as the heart and the brain but observed throughout the peripheral cardiovascular system. When an artery has a diameter reduction, acoustic radiation originating from this constriction propagates through soft tissues and reaches to skin surface. Therefore, these signals detected on skin surface may provide valuable information for diagnostic purposes. In this study, effects of acoustic radiation on skin surface due to a stenosis are investigated. Human upper arm is modeled using commercial finite element analysis software ADINA. Realistic geometries and soft tissue mechanical properties are employed. Acoustic pressure distribution due to constriction is modeled using related studies in literature and applied on inner surface of blood vessel. Harmonic analysis is performed for upper arm and pressure distribution on skin surface is obtained. It is observed that increasing level of stenosis leads to an increase in pressure amplitudes on skin surface where the region which is closest to the constricted artery has the highest pressure amplitudes.


Investigation of fluid structure interaction in cardiovascular system from diagnostic and pathological perspective
Salman, Hüseyin Enes; Yazıcıoğlu, Yiğit; Sert, Cüneyt; Department of Mechanical Engineering (2012)
Atherosclerosis is a disease of the cardiovascular system where a stenosis may develop in an artery which is an abnormal narrowing in the blood vessel that adversely affects the blood flow. Due to the constriction of the blood vessel, the flow is disturbed, forming a jet and recirculation downstream of the stenosis. Dynamic pressure fluctuations on the inner wall of the blood vessel leads to the vibration of the vessel structure and acoustic energy is propagated through the surrounding tissue that can be de...
Flow-induced vibration analysis of constricted artery models with surrounding soft tissue
Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (2017-10-01)
Arterial stenosis is a vascular pathology which leads to serious cardiovascular diseases. Blood flow through a constriction generates sound and vibration due to fluctuating turbulent pressures. Generated vibro-acoustic waves propagate through surrounding soft tissues and reach the skin surface and may provide valuable insight for noninvasive diagnostic purposes. Motivated by the aforementioned phenomena, vibration of constricted arteries is investigated employing computational models. The flow-induced press...
Nanopatterned tubular collagen scaffolds for vascular tissue engineering
Zorlutuna, Pınar; Hasırcı, Vasıf Nejat; Department of Biotechnology (2009)
One of the major causes of death in developed countries is cardiovascular disease that affects small and medium sized blood vessels. In most cases autologous grafts have to be used which have limited availability. A functional tissue engineered vessel can be the ultimate solution for vascular reconstruction. Tissue engineered constructs with cells growing in an organized manner have been shown to have improved mechanical properties. In the present study collagen scaffolds with 650 nm, 500 nm and 332.5 nm wi...
Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration
Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Springer Science and Business Media LLC, 2019-08-01)
Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibility of noninvasive acoustic detection of the peripheral arterial stenosis is investigated using the vibration responses by means of experimental and computational models. Latex rubber tube is u...
Analysis of cytochrome P4501A1 genetic polymorphisms in patients with ischemic stroke
Adalı, Ayşe Çınar; Adalı, Orhan; Demirdöğen, Birsen Can; Department of Biochemistry (2011)
Stroke is the third leading cause of death worldwide and results in serious disabilities. Cytochrome P450 1A1 gene (CYP1A1) is a highly polymorphic gene encoding its corresponding xenobiotic metabolizing enzyme which is responsible from the metabolism of carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are engaged with the formation of free radicals. Atherosclerosis is a major cause of ischemic stroke and this pathology may be associated with the disruption of vascular homeostasis due to the format...
Citation Formats
H. E. Salman and Y. Yazıcıoğlu, “Investigation of on skin surface response due to acoustic radiation from stenosed blood vessels,” 2015, vol. 25, Accessed: 00, 2020. [Online]. Available: