Knowledge discovery in microarray data of bioinformatics

Kocabaş, Fahri Salih
This thesis analyzes major microarray repositories and presents a metadata framework both to address the current issues and to promote the main operations such as knowledge discovery, sharing, integration, and exchange. The proposed framework is demonstrated in a case study on real data and can be used for other high throughput repositories in biomedical domain. Not only the number of microarray experimentation increases, but also the size and complexity of the results rise in response to biomedical inquiries. And, experiment results are significant when examined in a batch and placed in a biological context. There have been standardization initiatives on content, object model, exchange format, and ontology. However, they have proprietary information space. There are backlogs and the data cannot be exchanged among the repositories. There is a need for a format and data management standard at present.iv v We introduced a metadata framework to include metadata card and semantic nets to make the experiment results visible, understandable and usable. They are encoded in standard syntax encoding schemes and represented in XML/RDF. They can be integrated with other metadata cards, semantic nets and can be queried. They can be exchanged and shared. We demonstrated the performance and potential benefits with a case study on a microarray repository. This study does not replace any product on repositories. A metadata framework is required to manage such huge data. We state that the backlogs can be reduced, complex knowledge discovery queries and exchange of information can become possible with this metadata framework.


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Citation Formats
F. S. Kocabaş, “Knowledge discovery in microarray data of bioinformatics,” Ph.D. - Doctoral Program, Middle East Technical University, 2012.