The Synthesis of 6- and 7- membered heterocyclic ring systems fused to pyridine ring

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2013

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Dinçoflaz, Yasemin

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The synthesis of the nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities in biological systems. Among the various biologically active molecules, pyridine-fused ring systems are of prime importance on the grounds of their proven clinical roles. The coupling reactions with 6-membered heterocyclic compounds and diazepines gave rise to new pharmalogical compounds in recent years. Therefore, our object was the synthesis of pyridine-fused 6- and 7-membered heterocycles. Starting from bromopyridine, two different methods were applied for the synthesis of target compounds. In the first part of the this thesis, coupling products were synthesized using Sonogashira coupling reaction. After synthesis of the coupling derivatives, ring-closure under the basic conditions generated the heterocyclic units without using any catalyzer. In the second part of study, nicotinic acid and pyridopyranone derivatives were synthesized by using intramolecular cyclization reactions. The formed products were conscientiously purified and characterized by means of spectroscopics method.

Subject Keywords

Pyridine., Pyridinium compounds., Heterocyclic compounds., Chemistry, Organic., Bromopyridine.

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http://etd.lib.metu.edu.tr/upload/12615579/index.pdf
https://hdl.handle.net/11511/22429

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

Y. Dinçoflaz, “The Synthesis of 6- and 7- membered heterocyclic ring systems fused to pyridine ring,” M.S. - Master of Science, Middle East Technical University, 2013.