An Approach to the synyhesis of novel pyrrole fused heterocycles

Öztürk, Uğur Başak
Pyrrole and pyrrole derivatives are prominent building blocks in organic synthesis due to their biological activities and natural occurrence. For the formation of pyrrole derivatives, electrophilic cyclizations are considered efficient and significant processes. In this thesis, novel N-alkynyl-2-phenyl-substituted pyrrole derivatives were synthesized and electrophilic cyclization reactions of these compounds were investigated. Catalyst such as AuCl3, AuBr3, I2, ICl, FeCl3, InCl3 and Cu(OTf)2 were used for the ring closure studies.


The Synthesis of 6- and 7- membered heterocyclic ring systems fused to pyridine ring
Dinçoflaz, Yasemin; Balcı, Metin; Department of Chemistry (2013)
The synthesis of the nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities in biological systems. Among the various biologically active molecules, pyridine-fused ring systems are of prime importance on the grounds of their proven clinical roles. The coupling reactions with 6-membered heterocyclic compounds and diazepines gave rise to new pharmalogical compounds in recent years. Therefore, our object was the synthe...
A case study for control structure selection: Chlorination stage in the bleaching process of a pulp and paper plant
Qushsho'o, MH; Ozgen, C; Yetiş, Ülkü (2004-01-01)
The minimization of chlorinated organic compounds in the effluents of the chlorination unit of a pulp mill is proposed by the use of a control structure for the chlorination unit. Bleached pulp properties are related to the unbleached pulp properties: lignin content, brightness, and viscosity, as well as the amount of chlorinated organics in the bleachery effluent. The best feasible control pairings are studied by RGA and SVD methods. Kappa number of the bleached pulp (a measure of lignin content) and perce...
Türker, Burhan Lemi (Informa UK Limited, 2009-01-01)
A quantum chemical study, based on DFT theory is presented which considers certain selenium-containing naphthalene derivatives, including a keto group together with a Se atom embedded in either a five- or six-membered ring fused with naphthalene moiety. The corresponding enol structures also are considered. The quantum chemical and IR data collected are analyzed and NICS(0) values have been obtained.
Synthesis of indole fused heterocyclic compounds
Kaptı, Tolga; Balcı, Metin; Department of Chemistry (2013)
Nitrogen containing heterocyclic compounds show wide range of biological activities so their syntheses have always been attractive area in organic chemistry. Indole derivatives, which are one of the important example of these biological active compound, are precursors to many pharmaceuticals. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of pyrimidoindole and quinoline, which have been found to show important biological activities. In this stu...
A new strategy for the synthesis of pyridines from N-propargylic beta-enaminothiones
Kelgokmen, Yilmaz; Zora, Metin (Royal Society of Chemistry (RSC), 2019-03-07)
A new method for the synthesis of 2,4,5-trisubstituted pyridines from N-propargylic beta-enaminothiones is reported. beta-Enaminothiones were prepared by thionation of the corresponding beta-enaminones with Lawesson's reagent. When treated with diisopropylamine in DMF at room temperature, N-propargylic beta-enaminothiones yielded 2,4,5-trisubstituted pyridines in moderate to high yields, along with small amounts of 2-methylene-2,3-dihydro-1,4-thiazepines. The reaction was found to be general for a broad ran...
Citation Formats
U. B. Öztürk, “An Approach to the synyhesis of novel pyrrole fused heterocycles,” M.S. - Master of Science, Middle East Technical University, 2016.