Design of a modular orthopedic implant

Erkan, Onur Mert
Bone fracture due to trauma and bone defects by birth are very common in orthopedics, making their treatment crucial. In this study, a novel design to treat upper arm fractures is introduced and assessed mechanically. The design offers medical doctors longitudinal and angular flexibility when compared to widely used orthopedic plates. Hence the new design covers a variety of fracture types. Earlier conceptual designs are reviewed to demonstrate the progress of design. Mechanical performance of the final design is evaluated using analytic methods, finite element analysis and physical experiments. Assessment was based on a safe axial external load of 15 kgf suggested by the medical doctors and focused on the rigidity problems caused by modularity, along with strength concerns. It is proven in this study that the novel design can fix the fracture successfully, even under the aforementioned external load.


Mechanical design and analysis of a novel fixation device for human bone fractures
Yenigün, Çağrı; Tönük, Ergin; Oğuz, Erbil; Department of Biomedical Engineering (2016)
Fixation of bone fractures over a desired time period is one of the most important requirement for their healing processes. Fracture fixation devices are designed to satisfy particular requirements for different types of bone fractures. Conventional and locking plates, intramedullary rods and screws of trauma surgery, and polyaxial screws, connectors and rods of spinal surgery are the examples of contemporary implants for varying bones and their fractures. The mentioned fixation system is inspired from spin...
Development of a siRNA delivery system for the treatment of osteoporosis
Sezlev Bilecen, Deniz; Hasırcı, Vasıf Nejat; Uludağ, Hasan; Department of Biotechnology (2018)
Osteoporosis, the most common disease of bone, is a skeletal disorder associated with low bone mass, increase in bone fragility and in susceptibility to fractures. The high bone resorption rate is shown to be due to increased number and activity of the osteoclasts. Receptor Activator of Nuclear Factor kappa B (RANK)/ Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) system plays a crucial role in osteoclast differentiation and bone remodeling. RANKL participates in differentiation and activation o...
Selenium doped calcium phosphate biomimetic coating on Ti6Al4V orthopedic implant material for anti-cancer and anti-bacterial purposes
Yılmaz, Bengi; Evis, Zafer; Banerjee, Sreeparna; Department of Biomedical Engineering (2014)
In order to prevent recurrent osteosarcoma in patients undergone surgical resection for implant insertion and infection around implant site, which is a very common complication after surgery, it is very important to functionalize the surface. In this study, to combine the effective antioxidant and potential anti-cancer and anti-bacterial properties of selenium with the high biocompatibility and bioactivity of hydroxyapatite, selenium was added to the structure of hydroxyapatite via biomimetic method and coa...
Local delivery of bioactive agents for bone tissue engineering
Alissa Alam, Hani; Keskin, Dilek; Özen, Can; Department of Biotechnology (2017)
Many cases of bone defects require bone grafts addition into the body. Bone tissue substitutes have more advantages over other bone grafts because of low infection risk and abundance of materials. Local delivery of drugs or bioactive agents can help in these diseases’ treatments and bone growth overall while avoiding side effects or drug interference. To accelerate local bone regrowth, a research about developing a controlled local release system of bioactive agents to bone cells was conducted in this study...
Biological Responses of Ceramic Bone Spacers Produced by Green Processing of Additively Manufactured Thin Meshes
Minguella-Canela, Joaquim; Calero, Jose Antonio; Korkusuz, Feza; Korkusuz, Petek; Kankılıç, Berna; Bilgiç, Elif; De los Santos-López, M. Antonia (MDPI AG, 2020-5-30)
Bone spacers are exclusively used for replacing the tissue after trauma and/or diseases. Ceramic materials bring positive opportunities to enhance greater osteointegration and performance of implants, yet processing of porous geometries can be challenging. Additive Manufacturing (AM) opens opportunities to grade porosity levels in a part; however, its productivity may be low due to its batch processing approach. The paper studies the biological responses yielded by hydroxyapatite with beta -TCP (tricalcium ...
Citation Formats
O. M. Erkan, “Design of a modular orthopedic implant,” M.S. - Master of Science, Middle East Technical University, 2015.