Design of a modular orthopedic implant

Erkan, Onur Mert
Bone fracture due to trauma and bone defects by birth are very common in orthopedics, making their treatment crucial. In this study, a novel design to treat upper arm fractures is introduced and assessed mechanically. The design offers medical doctors longitudinal and angular flexibility when compared to widely used orthopedic plates. Hence the new design covers a variety of fracture types. Earlier conceptual designs are reviewed to demonstrate the progress of design. Mechanical performance of the final design is evaluated using analytic methods, finite element analysis and physical experiments. Assessment was based on a safe axial external load of 15 kgf suggested by the medical doctors and focused on the rigidity problems caused by modularity, along with strength concerns. It is proven in this study that the novel design can fix the fracture successfully, even under the aforementioned external load.


Mechanical design and analysis of a novel fixation device for human bone fractures
Yenigün, Çağrı; Tönük, Ergin; Oğuz, Erbil; Department of Biomedical Engineering (2016)
Fixation of bone fractures over a desired time period is one of the most important requirement for their healing processes. Fracture fixation devices are designed to satisfy particular requirements for different types of bone fractures. Conventional and locking plates, intramedullary rods and screws of trauma surgery, and polyaxial screws, connectors and rods of spinal surgery are the examples of contemporary implants for varying bones and their fractures. The mentioned fixation system is inspired from spin...
Development of a siRNA delivery system for the treatment of osteoporosis
Sezlev Bilecen, Deniz; Hasırcı, Vasıf Nejat; Uludağ, Hasan; Department of Biotechnology (2018)
Osteoporosis, the most common disease of bone, is a skeletal disorder associated with low bone mass, increase in bone fragility and in susceptibility to fractures. The high bone resorption rate is shown to be due to increased number and activity of the osteoclasts. Receptor Activator of Nuclear Factor kappa B (RANK)/ Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) system plays a crucial role in osteoclast differentiation and bone remodeling. RANKL participates in differentiation and activation o...
Local delivery of bioactive agents for bone tissue engineering
Alissa Alam, Hani; Keskin, Dilek; Özen, Can; Department of Biotechnology (2017)
Many cases of bone defects require bone grafts addition into the body. Bone tissue substitutes have more advantages over other bone grafts because of low infection risk and abundance of materials. Local delivery of drugs or bioactive agents can help in these diseases’ treatments and bone growth overall while avoiding side effects or drug interference. To accelerate local bone regrowth, a research about developing a controlled local release system of bioactive agents to bone cells was conducted in this study...
Biodegradable hydroxyapatite - Polymer composites
Durucan, Caner (2001-04-01)
The fracture of bone due to trauma or due to natural aging is one of the most frequent types of tissue failures. Treatment frequently requires the implantation of ct temporary or permanent prosthesis. The implanted materials may include the components of artificial joints, plates, and screws for fracture fixation. Typically, such implants are intended only to provide structural support or to serve as templates for bone re-growth. In general they are intended to remain in place for the life of the patient or...
Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings
TAMAY, DİLARA GÖKSU; Gokyer, Seyda; Schmidt, Jurgen; Vladescu, Alina; HURİ, PINAR; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2022-01-12)
In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium-...
Citation Formats
O. M. Erkan, “Design of a modular orthopedic implant,” M.S. - Master of Science, Middle East Technical University, 2015.