Blood supply network design

Download

index.pdf

Date

2016

Author

Yegül, Mert

Metadata

Show full item record

Item Usage Stats

217
views

84
downloads

In our study, we consider a joint location-inventory-routing problem with multiple location layers for a distinctive and regionalized blood supply network design. We formulate the problem as a mixed-integer nonlinear programming model and present an optimal solution method for the problem. However, solving medium and large-sized problem instances for the optimal solution turns out to be impractical. Therefore, we also develop several heuristic methods based on decomposition and simulated annealing techniques. We conduct extensive computational studies on numerous test problems and evaluate the performance of the solution methods proposed. Our results show that simulated annealing heuristic clearly outperforms other solution methods.

Subject Keywords

Blood banks., Inventory control., Logistics, Blood

URI

http://etd.lib.metu.edu.tr/upload/12620599/index.pdf
https://hdl.handle.net/11511/26110

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Rare cell enrichment from blood by using dielectrophoresis Özkayar, Gürhan; Külah, Haluk; Department of Biomedical Engineering (2015) Dielectrophoresis (DEP) is a technique used for separating particles with different sizes and/or dielectric properties. Fabrication of microelectrodes, thanks to MEMS technology, allows DEP to be applied in biomedical applications such as manipulation, separation, and enrichment of targeted cells from untargeted ones without any labeling. Especially, rare cell detection from blood occupies an important place in diagnostics of fatal diseases such as cancer. Circulating tumor cells (CTCs) that are shed into c...
A blood distribution system: an application to the Turkish Red Crescent Kurt, Atıl; Azizoğlu, Meral; Çetinkaya, Ferda Can; Department of Industrial Engineering (2018) In this study, we consider the blood distribution system in Turkey and focus on Central Anatolian Regional Blood Center. Our problem differs from the classical distribution problems as it resides irradiation centers, urgent demands, vehicle availability and traveling time restrictions. In this study, we considered two problems. To address the first problem, we develop a mixed integer linear program with two objectives: maximizing the demand satisfaction and minimizing total time travelled by the vehicles. W...
Red and white blood cell classification using Artificial Neural Networks Çelebi, Simge; null, null; Burkay Çöteli, Mert (American Institute of Mathematical Sciences (AIMS), 2018) Blood cell classification is a recent topic for scientists working on the diagnosis of blood cell related illnesses. As the number of computer vision (CV) applications is increasing to improve quality of human life, it spreads in the areas of autonomous drive, surveillance, robotic applications, telecommunications and etc. The number of CV applications also increases in the medical sector due the decreasing value of doctors per patient ratio (DPPR) in urban and suburban areas. A doctor working in such areas...
Blood compatibility of polymers derived from natural materials Fedel, Mariangela; Endoğan Tanır, Tuğba; Hasırcı, Nesrin; Maniglio, Devid; Morelli, Andrea; Chiellini, Federica; Motta, Antonella (2012-07-01) Several polymers derived from natural materials are effective for tissue engineering or drug delivery applications, due to specific properties, such as biocompatibility, biodegradability, and structural activity. Their blood compatibility needs to be carefully evaluated to avoid thrombosis and other material-related adverse events in the hematic environment. We compared the surface properties and blood compatibility of protein and polysaccharide polymers, including fibroin, gelatin, and chitosan. Both fibro...
A high-throughput microfluidic rare cell enrichment system based on dielectrophoresis and filtering Ozkayar, Gurhan; Yalcin, Yagmur Demircan; Ozgur, Ebru; Gündüz, Ufuk; Külah, Haluk (2016-05-27) In this study, a MEMS-based microfluidic device combining DEP-based cell manipulation with size-based filtration for the enrichment of CTCs from blood with high-throughput was developed. Positive-DEP (pDEP) force and the hydrodynamic force have been used to fine-tune the cell movement over the planar electrodes (sliding) at a high flow rate (30 mu l/min). While smaller sized RBCs passed through the gaps and were directed to the waste channels, cancer cells (K562 cells) were filtered and directed to the canc...

Citation Formats

M. Yegül, “Blood supply network design,” Ph.D. - Doctoral Program, Middle East Technical University, 2016.