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Blood compatibility of polymers derived from natural materials
Date
2012-07-01
Author
Fedel, Mariangela
Endoğan Tanır, Tuğba
Hasırcı, Nesrin
Maniglio, Devid
Morelli, Andrea
Chiellini, Federica
Motta, Antonella
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Several polymers derived from natural materials are effective for tissue engineering or drug delivery applications, due to specific properties, such as biocompatibility, biodegradability, and structural activity. Their blood compatibility needs to be carefully evaluated to avoid thrombosis and other material-related adverse events in the hematic environment. We compared the surface properties and blood compatibility of protein and polysaccharide polymers, including fibroin, gelatin, and chitosan. Both fibroin and chitosan showed good hemocompatibility, with low platelet adhesion and spreading. Chitosan induced strong interactions with plasma proteins, especially with albumin. It was hypothesized that surface passivation by albumin inhibited the adsorption of other procoagulant and proadhesive proteins on chitosan and fibroin films, which limited platelet spreading. However, the significant and rapid polymer swelling encouraged protein entrapment within the soft, gelatin films, inducing higher platelet adhesion and activation. Thrombin generation assay confirmed the higher blood compatibility of chitosan and fibroin with regard to clotting.
Subject Keywords
Fibroin
,
Gelatin
,
Chitosan
,
Plasma protein adsorption
,
Thrombin
,
Platelet adhesion
,
Platelet activation
,
Platelet spreading
URI
https://hdl.handle.net/11511/29852
Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
DOI
https://doi.org/10.1177/0883911512446060
Collections
Graduate School of Natural and Applied Sciences, Article
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M. Fedel et al., “Blood compatibility of polymers derived from natural materials,”
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
, pp. 295–312, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/29852.