Blood compatibility of polymers derived from natural materials

Date

2012-07-01

Author

Fedel, Mariangela
Endoğan Tanır, Tuğba
Hasırcı, Nesrin
Maniglio, Devid
Morelli, Andrea
Chiellini, Federica
Motta, Antonella

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Several polymers derived from natural materials are effective for tissue engineering or drug delivery applications, due to specific properties, such as biocompatibility, biodegradability, and structural activity. Their blood compatibility needs to be carefully evaluated to avoid thrombosis and other material-related adverse events in the hematic environment. We compared the surface properties and blood compatibility of protein and polysaccharide polymers, including fibroin, gelatin, and chitosan. Both fibroin and chitosan showed good hemocompatibility, with low platelet adhesion and spreading. Chitosan induced strong interactions with plasma proteins, especially with albumin. It was hypothesized that surface passivation by albumin inhibited the adsorption of other procoagulant and proadhesive proteins on chitosan and fibroin films, which limited platelet spreading. However, the significant and rapid polymer swelling encouraged protein entrapment within the soft, gelatin films, inducing higher platelet adhesion and activation. Thrombin generation assay confirmed the higher blood compatibility of chitosan and fibroin with regard to clotting.

Subject Keywords

Fibroin, Gelatin, Chitosan, Plasma protein adsorption, Thrombin, Platelet adhesion, Platelet activation, Platelet spreading

URI

https://hdl.handle.net/11511/29852

Journal

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS

DOI

https://doi.org/10.1177/0883911512446060

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

M. Fedel et al., “Blood compatibility of polymers derived from natural materials,” JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, pp. 295–312, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/29852.