Development of poly(trimethylene carbonate) based biodegradable microparticles

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2018
Şahin, Gözde
Microparticles are promising in many fields of application, such as polymeric drugs, drugs and vaccine delivery systems, cell markers because of their versatility. Since it is important that the particles should have a certain shape and size, various fabrication methods have been tried for the production of the particles such as bottom-up and top-down methods. One of the most recent and eligible method among them is Particle Replication in Non-wetting Templates (PRINT) technique. PRINT is a top-down fabrication technique used for the production of free particles with a specific shape and size. With this technique, it has been tried to produce particles from polymers that are used frequently in biomedical applications. Recently, poly(trimethylene carbonate) (PTMC) has become a prominent biomaterial due to its unique properties when compared to widely used polymers. In this study, PTMC based micro carriers were produced using the PRINT technique. Therefore, PTMC oligomers were synthesized by ring opening polymerization. The end group of the oligomers were double bonded with methacryloyl chloride so that the synthesized oligomers could be fabricated as particles of a certain shape and size. In order to apply the PRINT technique, masks with protruded patterns have been prepared with standard lithographic methods. With the help of these masks, non-wetting surface PFPE molds with indented patterns were created. The synthesized PTMC oligomers were poured onto the mold and crosslinked to take the shape of the mold cavities. The free particles produced were collected by the non-wetting surface of the mold, and their morphological characteristics were examined by scanning electron microscope (SEM) imaging technique. According to the results, rectangular particles with dimensions of 2 µm x 8 µm, and cylindrical and cubic PTMC based particles ranging from 2-100 µm were produced.  

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Citation Formats
G. Şahin, “Development of poly(trimethylene carbonate) based biodegradable microparticles,” M.S. - Master of Science, Middle East Technical University, 2018.