Design and characterization of capsaicin loaded nanoemulsions

Download

index.pdf

Date

2016

Author

Akbaş, Elif

Metadata

Show full item record

Item Usage Stats

385
views

147
downloads

In recent years, nanoemulsion based systems have been successfully used in food, medical and pharmaceutical applications as effective lipophilic carrier systems for nutraceuticals, drugs, antioxidants and antimicrobial agents. The primary active ingredient of chili pepper, capsaicin is a hydrophobic substance and was proved to be a compound showing good antimicrobial activity against various microorganisms. The aim of the proposed study was to prepare and characterize capsaicin loaded nanoemulsion systems. Nanoemulsions were prepared with emulsifiers Tween 80, lecithin and sucrose monopalmitate (SMP) by using microfluidization and ultrasonication at pH 7.4 and pH 3.8. Effect of glycerol addition and heating the coarse dispersions on nanoemulsion formation were also investigated. Antimicrobial activities of nanoemulsions were evaluated against well-known food pathogens Escherichia coli and Staphylococcus aureus. In the experiments, 2% capsaicin nanoemulsions decreased E.coli population up to 3.4 log after 15 min of contact time by using lecithin and S. aureus population up to 5.89 log after 2 hours of contact time by using Tween 80. The smallest particle size of 33.17 nm was obtained using SMP with microfluidization. Addition of glycerol to the continuous phase showed enhanced effect on the results for both homogenization types. Moreover, nanoemulsions processed by microfluidization exhibited enhanced physical properties and antimicrobial activity. NMR relaxometry technique helped to track changes in nanoemulsions that was associated with the other methods such as particle size, turbidity. In overall, nanoemulsions with improved functionality were obtained using capsaicin.

Subject Keywords

Capsaicin., Emulsions., Nanotechnology., Anti-infective agents.

URI

http://etd.lib.metu.edu.tr/upload/12620212/index.pdf
https://hdl.handle.net/11511/25897

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors Hawash, Mohammed; Jaradat, Nidal; Abualhasan, Murad; ŞÜKÜROĞLU, MURAT KADİR; Qaoud, Mohammed T.; Kahraman, Deniz Cansen; Daraghmeh, Heba; Maslamani, Leen; Sawafta, Mais; Ratrout, Ala; Issa, Linda (2023-12-01) Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly used class of medications worldwide for the last three decades. Objectives: This study aimed to design and synthesize a novel series of methoxyphenyl thiazole carboxamide derivatives and evaluate their cyclooxygenase (COX) suppressant and cytotoxic properties. Methods: The synthesized compounds were characterized using 1H, 13C-NMR, IR, and HRMS spectrum analysis and were evaluated for their selectivity towards COX-1 and CO...
Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings Gungor, Bilgi; Yagci, Fuat Cem; GÜRSEL, İHSAN; Gürsel, Mayda (2014-07-01) Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.
Formulation, characterization and antimicrobial effect of cinnamon oil nanoemulsions Yıldırım, Simge Tutku; Öztop, Halil Mecit; Soyer, Yeşim; Department of Food Engineering (2015) Activities of essential oils, such as antimicrobial, antioxidant and anticancer have been recognized for decades. To utilize the functionality of these materials in foods as natural additives instead of synthetic active materials, oil-in-water (O/W) nanoemulsions that are obtained by low and high-energy methods have been intensively explored in recent years. The purpose of this study was to formulate stable cinnamon oil nanoemulsions (NEs) having higher antimicrobial activity by using the low-energy approac...
EVALUATION OF ANTIBACTERIAL AND CARBONIC ANHYDRASE INHIBITORY POTENTIAL OF METHANOLIC EXTRACT OF &ITNARDOSTACHYS JATAMANSI&IT (D. DON) DC RHIZOMES Rehman, Tayyeba; Ahmad, Saeed; Abbasi, Waheed Mumtaz; Ahmad, Ashfaq; Bilal, Muhammad; Zaman, Muhammad Mohsin; Ghauri, Aymen Owais; Arshad, Adeel; Akhtar, Khalid (2017-09-01) Many antimicrobial drugs are going to become resistant to different pathogens, so the discovery of new antimicrobial products is an important public health concern. Nardostachys jatamansi (D. Don) DC (Valerianaceae) is an important traditional herbal medicine used as tranquillizer. CNS sedative. antiepilepsy, cardiotonic. diuretic, heptatonic, analgesic and in boils, itch and eye diseases. Carbonic anhydrase inhibitors are the potential source of treatment in case of glaucoma, hypertension and epilepsy and ...
Development of poly(trimethylene carbonate) based biodegradable microparticles Şahin, Gözde; Bat, Erhan; Tirkeş, Seha; Department of Chemical Engineering (2018) Microparticles are promising in many fields of application, such as polymeric drugs, drugs and vaccine delivery systems, cell markers because of their versatility. Since it is important that the particles should have a certain shape and size, various fabrication methods have been tried for the production of the particles such as bottom-up and top-down methods. One of the most recent and eligible method among them is Particle Replication in Non-wetting Templates (PRINT) technique. PRINT is a top-down fabrica...

Citation Formats

E. Akbaş, “Design and characterization of capsaicin loaded nanoemulsions,” M.S. - Master of Science, Middle East Technical University, 2016.