Synthesis, aqueous solution behavior and layer-bylayer self-assembly of poly(2-alkyl-2-oxazoline)s

Download

index.pdf

Date

2019

Author

Çağlı, Eda

Metadata

Show full item record

Item Usage Stats

423
views

165
downloads

Poly(2-alkyl-2-oxazoline)s (PAOXs), are of interest for biomedical applications due to their important biological properties such as nontoxicity and biocompatibility. PAOXs with short-alkyl chains exhibit temperature-responsive behaviour which is advantageous for various biomedical applications. This dissertation focused on synthesis, aqueous solution behaviour, post-functionalization and layer-by-layer (LbL) self-assembly of PAOXs. In addition, it aimed to examine the surface properties of PAOX LbL films and correlate them with biological properties of the multilayers. First, the effect of pH on aqueous solution behaviour of poly(2-isopropyl-2-oxazoline) (PIPOX) was examined. In this respect, the effect of PIPOX end group, concentration of polymer and salt on pH-induced self-association of PIPOX was examined. Second, the effect of PIPOX end-group on loading capacity and release profile of a model antibiotic, Chloramphenicol (CAP) from PIPOX aggregates was investigated at neutral and acidic pH at a physiologically related temperature. Third, the effect of side chain variation on surface and biological properties of PAOX LbL films has been examined. In this context, PAOXs with varying side chains were co-assembled with Tannic Acid (TA) at the surface using LbL technique. The effect of chemical nature of PAOX side chains, phase behaviour of PAOX and the binding strength between the layers on surface morphology, stability, wettability and stimuli-responsive drug release properties of the films were examined and correlated with anti-adhesive and antibacterial properties of the PAOX multilayers. Forth, PIPOX-hyd-Doxycycline conjugate was synthesized via hydrazone bond formation and characterized. Overall, this dissertation generated fundamental knowledge about aqueous solution behaviour of PAOXs and structure-property relationship in PAOX multilayer films.

Subject Keywords

Polymers in medicine., Biomedical materials.

URI

http://etd.lib.metu.edu.tr/upload/12623119/index.pdf
https://hdl.handle.net/11511/28023

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Synthesis, spectroscopic and computational analysis of nickel integrated germanium clusters Öğün, Sinem Esra; Nalbant Esentürk, Emren; Department of Chemistry (2014) Nanomaterials are attracting great deal of attention due to their wide range of applications such as in medicine, catalysis and electronics. The use of clusters either as seeds to synthesize larger molecular clusters or in assembled cluster materials is a promising way to prepare new nanomaterials. In particular, the possibility of clusters serving molecular control to design and tuning their properties to fit a particular application makes them more attractive in the search of new advanced materials. There...
Use of open linked data in bioinformatics space: A case study Çelebi, Remzi; GÜMÜŞ, ÖZGÜR; Aydın Son, Yeşim (2013-01-01) In the life sciences, semantic web can support many aspects of bio- and health informatics, with exciting applications appearing in areas ranging from plant genetics to drug discovery. Using semantic technologies with open linked data, provides two kinds of advantages: ability to search multiple datasets through a single framework and ability to search relationships and paths of relationships that go across different datasets. The Bio2RDF project creates a network of coherently linked data across the biolog...
Development of poly(trimethylene carbonate) based biodegradable microparticles Şahin, Gözde; Bat, Erhan; Tirkeş, Seha; Department of Chemical Engineering (2018) Microparticles are promising in many fields of application, such as polymeric drugs, drugs and vaccine delivery systems, cell markers because of their versatility. Since it is important that the particles should have a certain shape and size, various fabrication methods have been tried for the production of the particles such as bottom-up and top-down methods. One of the most recent and eligible method among them is Particle Replication in Non-wetting Templates (PRINT) technique. PRINT is a top-down fabrica...
Poly( amino acid)-based fibrous scaffolds modified with surface-pendant peptides for cartilage tissue engineering Svobodova, Jana; Proks, Vladimir; Karabiyik, Ozge; Koyuncu, Ayse Ceren Calikoglu; Kose, Gamze Torun; Rypacek, Frantisek; Studenovska, Hana (Wiley, 2017-03-01) In this study, fibrous scaffolds based on poly(gamma-benzyl-L-glutamate) (PBLG) were investigated in terms of the chondrogenic differentiation potential of human tooth germ stem cells (HTGSCs). Through the solution-assisted bonding of the fibres, fully connected scaffolds with pore sizes in the range 20-400 mu m were prepared. Biomimetic modification of the PBLG scaffolds was achieved by a two-step reaction procedure: first, aminolysis of the PBLG fibres' surface layers was performed, which resulted in an i...
Fatigue behavior of TiNi foams processed by the magnesium space holder technique Nakas, G. Ipek; Dericioğlu, Arcan Fehmi; Bor, Sakir (Elsevier BV, 2011-11-01) While the wide range of applications of TiNi alloys makes them highly appealing due to their shape memory and superelasticity properties, the production of TiNi in the porous form further enlarges their application fields. Porous TiNi alloys have been studied extensively for biomedical applications since their elastic modulus is similar to that of bone. Accordingly, TiNi foams have been widely characterized in terms of their various mechanical properties; however, their fatigue properties have not been well...

Citation Formats

E. Çağlı, “Synthesis, aqueous solution behavior and layer-bylayer self-assembly of poly(2-alkyl-2-oxazoline)s,” Ph.D. - Doctoral Program, Middle East Technical University, 2019.