Dilek Keskin

E-mail

dkeskin@metu.edu.tr

Department

Department of Engineering Sciences

ORCID

0000-0001-7824-488X

Scopus Author ID

36967297400

Web of Science Researcher ID

AAZ-6462-2020

Novel barium-doped-baghdadite incorporated PHBV-PCL composite fibrous scaffolds for bone tissue engineering Sadreddini, Sanaossadat; Jodati, Hossein; Evis, Zafer; Keskin, Dilek (2023-12-01) Bioceramic/polymer composites have dragged a lot of attention for treating hard tissue damage in recent years. In this study, we synthesized barium-doped baghdadite (Ba-BAG), as a novel bioceramic, and later developed fibr...
Diatom silica frustules-doped fibers for controlled release of melatonin for bone regeneration Deniz Dalgic, Ali; Atila, Deniz; Tezcaner, Ayşen; Gürses, Senih; Keskin, Dilek (2023-03-15) Sustained release of a bioactive agent from a tissue engineering scaffold is one of the most common strategies to improve regenerative potential of the construct. However, depending on the chemistry of the agent, achieving...
Improvement of bioactivity with dual bioceramic incorporation to nanofibrous PCL scaffolds Altunordu, Gercem; Tezcaner, Ayşen; Evis, Zafer; Keskin, Dilek (2023-03-01) Bone tissue injuries, diseases or related clinical interventions require bone tissue engineering (BTE) approaches for regeneration of large bone defects, especially for compromised situations. Most BTE applications in lite...
Injectable methacrylated gelatin/thiolated pectin hydrogels carrying melatonin/tideglusib-loaded core/shell PMMA/silk fibroin electrospun fibers for vital pulp regeneration Atila, Deniz; Keskin, Dilek; Lee, Yuan-Ling; Lin, Feng-Huei; Hasirci, Vasif; Tezcaner, Ayşen (2023-02-01) Use of injectable hydrogels attract attention in the regeneration of dental pulp due to their ability to fill non-uniform voids such as pulp cavities. Here, gelatin methacrylate/thiolated pectin hydrogels (GelMA/PecTH) car...
Functionalization of graphene oxide quantum dots for anticancer drug delivery Mohammed-Ahmed, Heba K.; Nakipoğlu, Mustafa; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer (2023-02-01) Graphene quantum dots (GQDs) have a wide range of applications in biomedical applications, particularly anticancer drug delivery. In this study, graphene oxide quantum dots conjugated with glucosamine and boric acid (GOQDs...
Alginate/gelatin/boron-doped hydroxyapatite-coated Ti implants: in vitro and in vivo evaluation of osseointegration Pazarçeviren, Ahmet Engin; Evis, Zafer; Dikmen, Tayfun; Altunbaş, Korhan; Yaprakçı, Mustafa V.; Keskin, Dilek; Tezcaner, Ayşen (2023-01-01) In this study, boron-doped hydroxyapatite (BHT)-loaded alginate/gelatin-based (A/G) hydrogel coating on Ti was fabricated to support bone integration through triggering osteoinduction, vascularization and immunomodulation....
Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations Motameni, Ali; Alshemary, Ammar Z.; Dalgic, Ali Deniz; Keskin, Dilek; Evis, Zafer (2022-09-01) Artificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak...
Seamless and robust alginate/gelatin coating on Ti-6Al-4V as a gap filling interphase Pazarçeviren, Ahmet Engin; Akbaba, Sema; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer (2022-04-01) Durable, biocompatible and interphases composed of interpenetrating network of alginate and gelatin (A/G) with long shelf-life were produced. Titanium implants were conditioned with acid:peroxide followed by sodium hydroxi...
Natural origin bilayer pullulan-PHBV scaffold for wound healing applications Dalgic, Ali Deniz; Koman, Ezgi; Karataş, Ayten; Tezcaner, Ayşen; Keskin, Dilek (2022-03-01) Skin tissue loss that occurs by injury and diseases can turn into chronic wounds as a result of complications alongside infection. Chronic wounds fail to heal by themselves and need advanced treatments like engineered woun...
Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of Vitamin C Demir, Gizem Cigdem; Erdemli, Özge; Keskin, Dilek; Tezcaner, Ayşen (2022-02-01) Recently, functional dressings that can protect the wound area from dehydration and bacterial infection and support healing have gained importance in place of passive dressings. This study aimed to develop temporary and re...

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