Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of Vitamin C

Date

2022-02-01

Author

Demir, Gizem Cigdem
Erdemli, Özge
Keskin, Dilek
Tezcaner, Ayşen

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Recently, functional dressings that can protect the wound area from dehydration and bacterial infection and support healing have gained importance in place of passive dressings. This study aimed to develop temporary and regenerative xanthan/gelatin (XGH) and keratin/xanthan/gelatin hydrogels (KXGHs) that have high absorption capacity and applicability as a wound dressing that can provide local delivery of Vitamin C (VC). Firstly, xanthan/gelatin hydrogels were produced by crosslinking with different glycerol concentrations and characterized to determine the hydrogel composition. According to their weight ratios, xanthan, gelatin, and glycerol hydrogels are named. If their weight ratio is 1:1:2 (w/w/w), the group name is selected as X1:GEL1:GLY2. X1: GEL1:GLY2 hydrogel was selected for biocompatibility, mechanical property, water vapor transmission rate (WVTR), and porosity. The addition of keratin to X1:GEL1:GLY2 improved L929 fibroblasts viability and increased protein release. Water vapor transmission of XGHs and KXGHs was between 3059.09 & PLUSMN; 126 and 4523 & PLUSMN; 133 g m(-2) d(-1); therefore, they can be suitable for granulating, low to moderate exudate wounds. XGH and KXGHs loaded with VC had higher water uptake, making it more convenient for exudate wounds. VC was released for 100 h, and VC containing XGHs and KXGHs increased the collagen synthesis of L929 fibroblasts. All of the hydrogels (XGH, KXGH, and VC-KXGHs) inhibited the bacteria transmission. In conclusion, our results suggest that VC-XGH and VC-KXGH can be candidates for temporary wound dressing materials for skin wounds.

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URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122565862&origin=inward
https://hdl.handle.net/11511/97016

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS

DOI

https://doi.org/10.1016/j.ijpharm.2021.121436

Collections

Department of Engineering Sciences, Article

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Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of vitamin c Demir, Gizem Çiğdem; Tezcaner, Ayşen; Department of Biotechnology (2021-1-10) In recent years, functional dressings that can protect the wound area from dehydration, support healing (interactive), and protect the wound against infections have gained importance instead of dry and passive dressings. In this study, it was aimed to develop temporary xanthan gelatin (XGH) and keratin xanthan gelatin hydrogels (KXGHs) that have high exudate absorption capacity, oxygen permeability, and applicability as a wound dressing for medical applications. Firstly, xanthan gelatin hydrogels were produ...
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Natural origin bilayer pullulan-PHBV scaffold for wound healing applications Dalgic, Ali Deniz; Koman, Ezgi; Karataş, Ayten; Tezcaner, Ayşen; Keskin, Dilek (2022-03-01) Skin tissue loss that occurs by injury and diseases can turn into chronic wounds as a result of complications alongside infection. Chronic wounds fail to heal by themselves and need advanced treatments like engineered wound dressings and regenerative scaffolds. In this study, a novel, natural origin, bilayer electrospun scaffold was produced from pullulan (PUL) and poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) biopolymers. PHBV production by Cupriavidus necator bacterial strain was optimized and produced ...

Citation Formats

G. C. Demir, Ö. Erdemli, D. Keskin, and A. Tezcaner, “Xanthan-gelatin and xanthan-gelatin-keratin wound dressings for local delivery of Vitamin C,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 614, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122565862&origin=inward.