Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations

Date

2022-09-01

Author

Motameni, Ali
Alshemary, Ammar Z.
Dalgic, Ali Deniz
Keskin, Dilek
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

173
views

0
downloads

Artificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak interaction and attachment with living hard tissue, and the inability to facilitate bone regeneration of calcified tissues rather than replacing them. In the present research, a novel combination of lanthanum (La3+) ions doped dicalcium phosphate (DCP) (La-DCP) and 1.5-3.5 wt.% of graphene oxide (GO) doped La-DCP bone cement materials were successfully synthesized and reported for the first time. Acid/base interaction between La-beta-tricalcium phosphate (La-beta TCP) and monocalcium phosphate monohydrate (MCPM) in the presence of water was the basis for making the La-DCP cements. The synthesized cements were characterized using the XRD, FTIR, FESEM, UV-Vis and TGA techniques. Produced material had La-DCP as in the monetite phase, and La-DCP particles were formed in agglomerates of irregular shapes. The presence of GO enhanced the growth rate of monetite particles, significantly decreased the setting time of the La-DCP bone cement, enhanced mechanical properties and enhanced the adsorption capacity of La-DCP. In vitro studies showed that synthesized GO/La-DCP bone cements were biocompatible, and the proliferation and differentiation properties of human osteosarcoma (Saos-2) cells were significantly improved with the addition of GO. In summary, the synthesized GO/La-DCP bone cement materials, which exhibit good biocompatibility and mechanical properties, have the potential to be employed in bone defect healing.

Subject Keywords

Dicalcium phosphate, Lanthanum, Graphene oxide, Mechanical properties, Biological properties, MECHANICAL-PROPERTIES, PHASE-TRANSFORMATION, PROTEIN ADSORPTION, HYDROXYAPATITE, LANTHANUM, BRUSHITE, MINERALIZATION, COMPOSITE, BIOCOMPATIBILITY, MONETITE

URI

https://hdl.handle.net/11511/100851

Journal

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY

DOI

https://doi.org/10.1007/s41779-022-00800-8

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

Preparation and characterization of hydroxyapatite containing acrylic bone cements Başgörenay, Burcu; Hasırcı, Nesrin; Department of Polymer Science and Technology (2004) Acrylic bone cements are one of the most important biomaterials used in orthopaedic surgery and dental applications to fill the cavities or provide mechanical interlock between prosthesis and the bone. Their biocompatibility can be increased by addition of different materials into the formulation, such as hydroxyapatite. Besides all the advantages, bone cements have several drawbacks including tissue necrosis, chemical necrosis, shrinkage of the cement and aseptic loosening. Therefore painstaking research a...
Resorbable PCEC/gelatin-bismuth doped bioglass-graphene oxide bilayer membranes for guided bone regeneration Pazarçeviren, Ahmet Engin; Evis, Zafer; Keskin, Dilek; Tezcaner, Ayşen (IOP Publishing, 2019-05-01) Guided bone regeneration (GBR) is a therapeutic modality applied prior to dental implant placement to increase bone density at the defect site or during placement for directing bone growth around implant. In this study, an asymmetric, bilayer structure was prepared by covalently bonding a dense polycaprolactone-polyethylene glycol-polycaprolactone (PCEC) membrane layer with a hydrogel layer composed of bismuth doped bioactive glass (BG, 45S5) and graphene oxide (GO) particles incorporated in gelatin. Struct...
Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings TAMAY, DİLARA GÖKSU; Gokyer, Seyda; Schmidt, Jurgen; Vladescu, Alina; HURİ, PINAR; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2022-01-12) In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium-...
Preparation and characterization of acrylic bone cements Endoğan, Tuğba; Hasırcı, Nesrin; Department of Chemistry (2005) Acrylic bone cements are used in dentistry and orthopedic surgery to fix prosthetic devices into the bone. Bone cements transfer and distribute the applied load and increase the load-carrying capacity of the prosthesis/cement/bone system with the help of mechanical bonding between the device and the bone. In spite of all their advantages, bone cements have several drawbacks such as insufficient mechanical properties, high exothermic polymerization temperature, release of monomer to the environmental tissue ...
Biodegradable hydroxyapatite - Polymer composites Durucan, Caner (2001-04-01) The fracture of bone due to trauma or due to natural aging is one of the most frequent types of tissue failures. Treatment frequently requires the implantation of ct temporary or permanent prosthesis. The implanted materials may include the components of artificial joints, plates, and screws for fracture fixation. Typically, such implants are intended only to provide structural support or to serve as templates for bone re-growth. In general they are intended to remain in place for the life of the patient or...

Citation Formats

A. Motameni, A. Z. Alshemary, A. D. Dalgic, D. Keskin, and Z. Evis, “Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations,” JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/100851.