An update on molecular biology and drug resistance mechanisms of multiple myeloma

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2015-12

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Mutlu, Pelin
Gündüz, Ufuk

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Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several factors to this, such as obesity, environmental factors, family history, genetic factors and monoclonal gammopathies of undetermined significance (MGUS) that have been implicated as potentially etiologic. Development of MM involves a series of complex molecular events, including chromosomal abnormalities, oncogene activation and growth factor dysregulation. Chemotherapy is the most commonly used treatment strategy in MM. However, MM is a difficult disease to treat because of its marked resistance to chemotherapy. MM has been shown to be commonly multidrug resistance (MDR)-negative at diagnosis and associated with a high incidence of MDR expression at relapse. This review deals with the molecular aspects of MM, drug resistance mechanisms during treatment and also possible new applications for overcoming drug resistance.

Subject Keywords

Molecular aspects, Drug resistance, Targeted drug delivery, Multiple myeloma

URI

https://hdl.handle.net/11511/28637

Journal

Crıtıcal Revıews In Oncology Hematology

DOI

https://doi.org/10.1016/j.critrevonc.2015.07.003

Collections

Department of Biology, Article

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Citation Formats

P. Mutlu and U. Gündüz, “An update on molecular biology and drug resistance mechanisms of multiple myeloma,” Crıtıcal Revıews In Oncology Hematology, pp. 413–424, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/28637.