İhsan Cihan Ayanoğlu

E-mail

ayanoglu@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-4300-1401

Scopus Author ID

57200036217

Web of Science Researcher ID

AAZ-5565-2020

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia Yilmaz, Ismail Cem; Dünüroğlu, Emre; Ayanoğlu, İhsan Cihan; İpekoğlu, Emre Mert; Yildirim, Muzaffer; GİRGİNKARDEŞLER, NOGAY; ÖZBEL, YUSUF; TÖZ, SERAY; ÖZBİLGİN, AHMET; Aykut, Gamze; Gursel, Ihsan; Gursel, Mayda (2022-11-01) Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania ...
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection YILMAZ, İSMAİL CEM; et. al. (2021-09-01) Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes the development and immunogenicity of SARS-CoV-2 VLP v...
Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells Bulut, Esin Alpdundar; Kocabas, Banu Bayyurt; Yazar, Volkan; Aykut, Gamze; GÜLER, ÜLKÜ; SALİH, BEKİR; Yilmaz, Naz Surucu; Ayanoğlu, İhsan Cihan; Polat, Muammer Merve; AKÇALI, KAMİL CAN; GÜRSEL, İHSAN; Gürsel, Mayda (2020-11-01) Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to host cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such t...
Altitudinal Effects on Innate Immune Response of a Subterranean Rodent Solak, Halil Mert; Yanchukov, Alexey; Colak, Faruk; MATUR, FERHAT; Sozen, Mustafa; Ayanoğlu, İhsan Cihan; Winternitz, Jamie C. (Zoological Society of Japan, 2020-02-01) Immune defense is costly to maintain and deploy, and the optimal investment into immune defense depends on risk of infection. Altitude is a natural environmental factor that is predicted to affect parasite abundance, with ...
Could Individuals From Countries Using BCG Vaccination Be Resistant to SARS-COV-2 Induced Infections? Ayanoğlu, İhsan Cihan; İpekoğlu, Emre Mert; Gürsel, Mayda (2020-01-01) The lower than expected number of SARS-CoV-2 cases in countries with fragile health systems is puzzling. Herein, we hypothesize that BCG vaccination policies and vaccine strain preferences adopted by different countries mi...
Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency Gul, Ersin; et. al. (2018-07-01) Background: Pathological inflammatory syndromes of unknown etiology are commonly observed in ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in patients with STING-associat...
Characterization of L. tropica secreted exosomes and development of exosome-based preventive vaccine against L. tropica induced cutaneous leishmaniasis Gungor, B.; Ayanoğlu, İhsan Cihan; Konig, Tincer G.; ÖZBEL, YUSUF; ÖZBİLGİN, AHMET; GİRGİNKARDEŞLER, NOGAY; TÖZ, SERAY; GÜRSEL, İHSAN; Gürsel, Mayda (2016-08-01)

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