Surface and modification of LP-SBA-15 with polyethyleneimine for celecoxib delivery

Farid, Ali
In this study LP-SBA-15 (LP stands for large pores) and LP-SBA-15-PEI (PEI stands for polyethyleneimine), ordered mesoporous silica support material utilized with different pore structure characteristics to investigate on their drug delivery system abilities like release and loading properties, regarding to their structural variability and implication of surface modification. Hydrothermal synthesis method was used for synthesis of LP-SBA-15 and surface functionalization was done by polymerization of hyperbranched polyethyleneimine inside pores. The referred functional group expected to interact with surface silanols on the silica supports, and this interaction expected to be enriched by introduction of amino groups to the silica surfaces. For organic modification, necessities of larger pore mesophases is obvious. Since, accessibility of pore is highly dependent on pore size and structure. Therefore, having larger pores provides higher chance to have large empty spaces inside pores, even after modification of pores. After functionalization, drug loading was carried out in ethanol. As a drug model, Celecoxib (CLX) was used for investigation on bioavailability and drug delivery systems characterizations which is nonsteroidal anti-inflammatory drug that shows highly hydrophobic quality and also has very low bioavailability. Effect of particle morphology and specific pH was analyzed on release properties and release experiment was done in two different pH (pH= 5.0 and pH= 7.4). In characterization part, LP-SBA-15 particles were characterized by using X-ray Diffraction (XRD), Small-Angle X-ray Spectrometry (SAXS), N2 adsorption - desorption, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS) and Thermogravimetric Analysis (TGA). Hence, several characterizations were applied for better understanding the bioavailability, morphology, crystallinity etc. Consequently, an enhanced release rate on drug delivery properties were observed for LP-SBA-15-PEI in comparison to commercial drug and non-polymerized sample. More specifically, 41% of loading for LP-SBA-15-CLX and 25% for LP-SBA-15-PEI were observed. Moreover, more than 80% release in both pH= 5.0 and pH= 7.4 for LP-SBA-15-PEI-CLX and less than 50% in case of LP-SBA-15-CLX were exhibited. Which introduces LP-SBA-15-PEI as a proper choice for drug delivery systems since the release percent of Celebrex itself were less than 60% in both cases.


Surface functionalization of sba-15 particles for celecoxib delivery
Gezer, Gamze; Yılmaz, Ayşen; Department of Chemistry (2013)
Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles w...
Surface functionalization of SBA-15 particles for amoxicillin delivery
Sevimli, Filiz; Yılmaz, Ayşen (2012-08-01)
The hydrothermally synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method with (3-aminopropyl) triethoxy silane, mercaptopropyl trimethoxy silane and triethoxy methyl silane in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. The adsorption and release properties of calcined and organic-functionalized mesoporous silicas containing terminal primary amine, organothiol and methyl groups toward amoxicillin have been investigated. ...
Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property
Eren, Zeynep Seda; Yılmaz, Ayşen; Department of Chemistry (2016)
Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-g...
Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release
Eren, Zeynep Seda; Tuncer, Sinem; Gezer, Gamze; Yildirim, Leyla Tatar; Banerjee, Sreeparna; Yılmaz, Ayşen (2016-11-15)
In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After ...
Blood compatibility of polymers derived from natural materials
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Several polymers derived from natural materials are effective for tissue engineering or drug delivery applications, due to specific properties, such as biocompatibility, biodegradability, and structural activity. Their blood compatibility needs to be carefully evaluated to avoid thrombosis and other material-related adverse events in the hematic environment. We compared the surface properties and blood compatibility of protein and polysaccharide polymers, including fibroin, gelatin, and chitosan. Both fibro...
Citation Formats
A. Farid, “Surface and modification of LP-SBA-15 with polyethyleneimine for celecoxib delivery,” M.S. - Master of Science, Middle East Technical University, 2017.