Protein-based materials in load-bearing tissue-engineering applications

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2014-01-01

Author

Sayin, Esen
Baran, Erkan Turker
Hasırcı, Vasıf Nejat

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Proteins such as collagen and elastin are robust molecules that constitute nanocomponents in the hierarchically organized ultrastructures of bone and tendon as well as in some of the soft tissues that have load-bearing functions. In the present paper, the macromolecular structure and function of the proteins are reviewed and the potential of mammalian and non-mammalian proteins in the engineering of load-bearing tissue substitutes are discussed. Chimeric proteins have become an important structural biomaterial source and their potential in tissue engineering is highlighted. Processing of proteins challenge investigators and in this review rapid prototyping and microfabrication are proposed as methods for obtaining precisely defined custom-built tissue engineered structures with intrinsic microarchitecture.

Subject Keywords

Biomaterial, Load bearing, Protein, Regeneration, Scaffold, Tissue engineering

URI

https://hdl.handle.net/11511/30299

Journal

REGENERATIVE MEDICINE

DOI

https://doi.org/10.2217/rme.14.52

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

E. Sayin, E. T. Baran, and V. N. Hasırcı, “Protein-based materials in load-bearing tissue-engineering applications,” REGENERATIVE MEDICINE, pp. 687–701, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30299.