Protein-based materials in load-bearing tissue-engineering applications

Download

index.pdf

Date

2014-01-01

Author

Sayin, Esen
Baran, Erkan Turker
Hasırcı, Vasıf Nejat

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

38
views

0
downloads

Proteins such as collagen and elastin are robust molecules that constitute nanocomponents in the hierarchically organized ultrastructures of bone and tendon as well as in some of the soft tissues that have load-bearing functions. In the present paper, the macromolecular structure and function of the proteins are reviewed and the potential of mammalian and non-mammalian proteins in the engineering of load-bearing tissue substitutes are discussed. Chimeric proteins have become an important structural biomaterial source and their potential in tissue engineering is highlighted. Processing of proteins challenge investigators and in this review rapid prototyping and microfabrication are proposed as methods for obtaining precisely defined custom-built tissue engineered structures with intrinsic microarchitecture.

Subject Keywords

Biomaterial, Load bearing, Protein, Regeneration, Scaffold, Tissue engineering

URI

https://hdl.handle.net/11511/30299

Journal

REGENERATIVE MEDICINE

DOI

https://doi.org/10.2217/rme.14.52

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Protein-Protein Interactions in Live Cells: Reinventing the Wheel Son, Çağdaş Devrim (2018-12-13) G protein-coupled receptors (GPCRs) are membrane proteins that mediate physiologicalresponse to a diverse array of stimuli. In humans, they mediate the action of hundreds ofpeptide hormones, sensory stimuli, odorants, neurotransmitters, and chemokines. GPCRs alsoare targets for ~40% of all currently marketed pharmaceuticals. These receptors traditionallybeen thought to act as monomeric units. However, recent evidence suggests that GPCRs mayform dimers as part of their normal trafficking and function. While ...
Contact guidance enhances the quality of a tissue engineered corneal stroma Vrana, E.; Builles, N.; Hindie, M.; Damour, O.; AYDINLI, ATİLLA; Hasırcı, Vasıf Nejat (2008-02-01) Corneal stroma is a very complex structure, composed of 200 lamellae of oriented collagen fibers. This highly complex nature of cornea is known to be important for its transparency and mechanical integrity. Thus, an artificial cornea design has to take into account this complex structure. In this study, behavior of human corneal keratocytes on collagen films patterned with parallel channels was investigated. Keratocytes proliferated well on films and reached confluency after 7 days in the incubation medium....
Stem Cell and Advanced Nano Bioceramic Interactions Kose, Sevil; Kankilic, Berna; Gizer, Merve; Dede, Eda Ciftci; Bayramlı, Erdal; KORKUSUZ, PETEK; KORKUSUZ, FEZA (2018-01-01) Bioceramics are type of biomaterials generally used for orthopaedic applications due to their similar structure with bone. Especially regarding to their osteoinductivity and osteoconductivity, they are used as biodegradable scaffolds for bone regeneration along with mesenchymal stem cells. Since chemical properties of bioceramics are important for regeneration of tissue, physical properties are also important for cell proliferation. In this respect, several different manufacturing methods are used for manuf...
Bone tissue engineering using macroporous PHA-PLA and PHBV scaffolds produced by additive manufacturing and wet spinning Alagöz, Ayşe Selcen; Hasırcı, Vasıf Nejat; Department of Biology (2016) Bone supports and protects organs of body, stores minerals, produces blood cells and enables the movement of body. In addition, bone regulates homeostasis by controlling the concentration of key electrolytes in the blood and in the storage of Ca+2 and PO43- ions. Trauma, tumor, nonunion fractures and diseases like osteoporosis lead to bone loss that affects millions of people. Current clinical treatments such as application of autograft and allograft for treatment of these problems are limited due to donor ...
Microfibrous scaffolds from poly(L-lactide-co-epsilon-caprolactone) blended with xeno-free collagen/hyaluronic acid for improvement of vascularization in tissue engineering applications KENAR, HALİME; Ozdogan, Candan Yilmaz; Dumlu, Cansu; DOĞER, EMEK; Kose, Gamze Torun; Hasırcı, Vasıf Nejat (2019-04-01) Success of 3D tissue substitutes in clinical applications depends on the presence of vascular networks in their structure. Accordingly, research in tissue engineering is focused on the stimulation of angiogenesis or generation of a vascular network in the scaffolds prior to implantation. A novel, xeno-free, collagen/hyaluronic acid-based poly(L-lactide-co-epsilon-caprolactone) (PLC/COL/HA) (20/9.5/0.5 w/w/w) microfibrous scaffold was produced by electrospinning. Collagen types I and III, and hyaluronic acid...

Citation Formats

E. Sayin, E. T. Baran, and V. N. Hasırcı, “Protein-based materials in load-bearing tissue-engineering applications,” REGENERATIVE MEDICINE, pp. 687–701, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30299.