pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam, Shahla
Skjeldal, Frode Miltzow
Griffiths, Gareth
Maelandsmo, Gunhild M.
Engebraten, Olav
Nystrom, Bo
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin
Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).


The Antiproliferative Effect of Celecoxib Loaded pNIPAM Nanoparticles
Bayyurt, Banu; Hasırcı, Vasıf Nejat (2012-09-01)
The aim of this study was to design a drug delivery system based on poly(N-isopropylacrylamide) (pNIPAM) nanoparticles (NPs). The model drug, Celecoxib, is a cyclooxygenase-2 inhibitor and has a great potential in chemoprevention and treatment of various cancer types, however, the clinical use is limited due to the side effects on the cardiovascular system which is most probably due to the high doses used in clinical applications. In this study, a novel nanoparticle preparation approach, nanoprecipitation, ...
pH Responsive nano carriers for anti cancer drug delivery
Bagherifam, Shahla; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat; Department of Polymer Science and Technology (2013)
In the recent years, development of various organic and inorganic nano-sized systems has gained great interests especially for cancer diagnosis and treatment and intense researches are carried out in this area. Regarding to the recent trends for drug delivery system design, the novel approaches for drug carriers are mainly based on development of smart and nano-size drug carriers which are targeted to cancer cells. Hence, for an effective tumor-targeted delivery device, besides its chemical structure furthe...
Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin
Bagherifam, Shahla; Griffiths, Gareth W.; Maelandsmo, Gunhild M.; Nystrom, Bo; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2015-01-01)
Poly(sebacic anhydride) (PSA) is a promising polymer for the production of drug delivery vehicles. The aim of this work is to study the effect of preparation parameters on the quality of the nanoparticles. In this study, doxorubicin (DOX)-loaded PSA nanocapsules were prepared by an emulsion method. Effects of factors such as type of organic solvent, co-solute (surfactant) and its concentration on drug-loading efficiency, particle size and size distribution, morphology and release profile were examined to ga...
The design and synthesis of a photo-controlled, peptide-based potential drug carrier
Parlak Khalily, Melek; Özçubukçu, Salih (The Scientific and Technological Research Council of Turkey, 2018-01-01)
Our focus in this study is on the design and synthesis of a light-responsive peptide-based nanocarrier in order to develop effective and biocompatible drug delivery systems. The synthesized nanocarrier is basically composed of peptide amphiphiles comprising a micelle forming a Pro-Pro-Pro-Lys-Lys-Lys peptide sequence with an attached anthracene fluorophore Anthracene containing an inner core of the micelle can serve as a storage site for poorly water-soluble drugs. Moreover, anthracenes that come in close p...
pH responsive release of curcumin from photocrosslinked pectin/gelatin hydrogel wound dressings
Bostancı, Nazlı Seray; Büyüksungur, Senem; Hasırcı, Nesrin; Tezcaner, Ayşen (2022-01-01)
© 2022 Elsevier B.V.The aim of this study was to develop hydrogel wound dressings made of photocrosslinkable pectin and gelatin with pH dependent release of curcumin, an antimicrobial agent. Methacrylated forms of pectin and gelatin (PeMA and GelMA, respectively) were synthesized, and hydrogels were prepared with different compositions (1:1, 1:2 and 1:3 v/v ratios of PeMA and GelMA) by UV exposure. Pure GelMA was used as control group. Average pore diameter of hydrogels with the highest PeMA content (P1:G1)...
Citation Formats
S. Bagherifam et al., “pH-Responsive Nano Carriers for Doxorubicin Delivery,” PHARMACEUTICAL RESEARCH, pp. 1249–1263, 2015, Accessed: 00, 2020. [Online]. Available: