pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam, Shahla
Skjeldal, Frode Miltzow
Griffiths, Gareth
Maelandsmo, Gunhild M.
Engebraten, Olav
Nystrom, Bo
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin
Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).


The Antiproliferative Effect of Celecoxib Loaded pNIPAM Nanoparticles
Bayyurt, Banu; Hasırcı, Vasıf Nejat (2012-09-01)
The aim of this study was to design a drug delivery system based on poly(N-isopropylacrylamide) (pNIPAM) nanoparticles (NPs). The model drug, Celecoxib, is a cyclooxygenase-2 inhibitor and has a great potential in chemoprevention and treatment of various cancer types, however, the clinical use is limited due to the side effects on the cardiovascular system which is most probably due to the high doses used in clinical applications. In this study, a novel nanoparticle preparation approach, nanoprecipitation, ...
pH Responsive nano carriers for anti cancer drug delivery
Bagherifam, Shahla; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat; Department of Polymer Science and Technology (2013)
In the recent years, development of various organic and inorganic nano-sized systems has gained great interests especially for cancer diagnosis and treatment and intense researches are carried out in this area. Regarding to the recent trends for drug delivery system design, the novel approaches for drug carriers are mainly based on development of smart and nano-size drug carriers which are targeted to cancer cells. Hence, for an effective tumor-targeted delivery device, besides its chemical structure furthe...
Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro
Hakki, SS; Nohutcu, RM; Hakki, EE; Berry, JE; Akkaya, Mahinur; Somerman, MJ (Wiley, 2005-09-01)
Background: The aim of this study was to determine the effects of basic-fibroblast growth factor (b-FGF) and/or dexamethasone (Dex) on cementoblasts in vitro.
Bioprocess development for thermostable glucose isomerase production
Angardi, Vahideh; Çalık, Pınar; Department of Chemical Engineering (2011)
In this study, process development for glucose isomerase (GI) was aimed. In this context, firstly, thermostable xyl genes, PCR amplified from Thermus thermophilus and Pyrococcus furiosus cells, were recombined to the E.coli BL21 (DE3) and P.pastoris strains, respectively. But significant increase in the term of GI activity compared with wild type cells only detected in recombinant E.coli strain so this strain was selected for further experiments. Then, the effect of different natural and artificial inducers...
Silver nanoparticles-tragacanth gel as a green membrane for effective extraction and determination of capecitabine
Hajizadeh, Salahaddin; Farhadi, Khalil; Molaei, Rahim; Forough, Mehrdad (Wiley, 2020-07-01)
A novel eco-friendly and effective electromembrane extraction method combining high-performance liquid chromatography with UV detection was developed for the enrichment and determination of capecitabine. Tragacanth-silver nanoparticles conjugated gel was prepared by dissolving the tragacanth powder in synthesized silver nanoparticles solution and was used as a green membrane in electromembrane extraction. The porosity and presence of silver nanoparticles in the gel were characterized by field emission scann...
Citation Formats
S. Bagherifam et al., “pH-Responsive Nano Carriers for Doxorubicin Delivery,” PHARMACEUTICAL RESEARCH, pp. 1249–1263, 2015, Accessed: 00, 2020. [Online]. Available: