Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin

Bagherifam, Shahla
Griffiths, Gareth W.
Maelandsmo, Gunhild M.
Nystrom, Bo
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin
Poly(sebacic anhydride) (PSA) is a promising polymer for the production of drug delivery vehicles. The aim of this work is to study the effect of preparation parameters on the quality of the nanoparticles. In this study, doxorubicin (DOX)-loaded PSA nanocapsules were prepared by an emulsion method. Effects of factors such as type of organic solvent, co-solute (surfactant) and its concentration on drug-loading efficiency, particle size and size distribution, morphology and release profile were examined to gain insight in the preparation and stability of nanostructures. Particles with sizes in the range of 218-1198 nm were prepared. The smallest particles with a narrow size distribution were prepared by using polyvinyl alcohol as a co-solute and dichloromethane as a solvent. Efficiency and intracellular release of doxorubicin from the formulated particles were studied on MDA-MB-231 cells. It was observed that DOX-loaded PSA particles can diffuse into the cells and intracellular antitumour activity is directly related to the released amount of drug from the PSA nanocapsules.


pH-Responsive Nano Carriers for Doxorubicin Delivery
Bagherifam, Shahla; Skjeldal, Frode Miltzow; Griffiths, Gareth; Maelandsmo, Gunhild M.; Engebraten, Olav; Nystrom, Bo; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2015-04-01)
Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).
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Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and destructive side effects. For this purpose, magnetic generation 4 dendrimeric nanoparticles were prepared to carry chemotherapeutic agent doxorubicin (G 4-DOX) and immune modulator polyinosinic:polycytidylic acid [Poly(I:C)]. As previously reported, DOX and Poly(I:C) was loaded onto G 4 nanoparticles (PIC-G 4-DOX). Cellular internalization study using con...
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A novel eco-friendly and effective electromembrane extraction method combining high-performance liquid chromatography with UV detection was developed for the enrichment and determination of capecitabine. Tragacanth-silver nanoparticles conjugated gel was prepared by dissolving the tragacanth powder in synthesized silver nanoparticles solution and was used as a green membrane in electromembrane extraction. The porosity and presence of silver nanoparticles in the gel were characterized by field emission scann...
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In this work, poly(methyl methacrylate), PMMA, and its composites involving montmorillonites modified with different quaternary ammonium salts were prepared and characterized by X-ray Diffraction, XRD, Transmission Electron Microscopy, TEM, Thermogravimetry, TGA and direct pyrolysis mass spectrometry, DPMS. Increase in the interlayer spacing of the silicate layers compared to the corresponding organically modified clay was detected in X-ray diffractograms for all the PMMA composites in accordance with TEM r...
Poly(methyl methacrylate)-octatrimethylsiloxy polyhedral oligomeric silsesquioxane composite syntactic foams with bimodal pores
Ozkutlu, Merve; Bayram, Göknur; Dilek Hacıhabiboğlu, Çerağ (2021-06-01)
Bimodal poly(methyl methacrylate) (PMMA) foams are produced with a new method combining syntactic foam production and supercritical CO2 (scCO2) foaming. Bimodal pore structure offers several potential advantages to foam properties, such as reduced mass density and excellent thermal and sound insulation properties. To produce the foams, first PMMA composites are produced with hollow glass microspheres (HGMs) and octatrimethylsiloxy polyhedral oligomeric silsesquioxane (POSS) nanoparticles using a twin screw ...
Citation Formats
S. Bagherifam, G. W. Griffiths, G. M. Maelandsmo, B. Nystrom, V. N. Hasırcı, and N. Hasırcı, “Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin,” JOURNAL OF MICROENCAPSULATION, pp. 166–174, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30507.