Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

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2011-10-01

Author

BARAN, YUSUF
Bielawski, Jacek
Gündüz, Ufuk
Ogretmen, Besim

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Purpose Drug resistance presents a major obstacle for the treatment of some patients with chronic myeloid leukemia (CML). Pro-apoptotic ceramide mediates imatinib-induced apoptosis, and metabolism of ceramide by glucosylceramide synthase (GCS) activity, converting ceramide to glucosyl ceramide, might contribute to imatinib resistance. In this study, we investigated the role of ceramide metabolism by GCS in the regulation of imatinib-induced apoptosis in drug-sensitive and drug-resistant K562 and K562/IMA-0.2 and K562/IMA-1 human CML cells, which exhibit about 2.3- and 19-fold imatinib resistance, respectively.

Subject Keywords

Drug resistance , Ceramide, Apoptosis, Glucosylceramide, Drug resistance, CML

URI

https://hdl.handle.net/11511/30705

Journal

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

DOI

https://doi.org/10.1007/s00432-011-1016-y

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

Y. BARAN, J. Bielawski, U. Gündüz, and B. Ogretmen, “Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation,” JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, pp. 1535–1544, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30705.