Antibiotic release from biodegradable PHBV microparticles

Sendil, D
Gursel, I
Wise, DL
Hasırcı, Vasıf Nejat
For the treatment of periodontal diseases, design of a controlled release system seemed very appropriate for an effective, long term result. In this study a novel, biodegradable microbial polyester, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), PHBV of various valerate contents containing a well established antibiotic, tetracycline, known to be effective against many of the periodontal disease related microorganisms, was used in the construction of a controlled release system. Tetracycline was loaded in the PHBV microspheres and microcapsules both in its acidic (TC) and in neutral form (TCN). Microcapsules of PHBV were prepared under different conditions using w/o/w double emulsion and their properties such as encapsulation efficiency, loading, release characteristics, and morphological properties were investigated. It was found that concentration of emulsifiers polyvinyl alcohol (PVA) and gelatin (varied between 0-4%) influenced the encapsulation efficiency appreciably. In order to increase encapsulation efficiency (from the obtained range of 18.1-30.1%) and slow down the release of the highly soluble tetracycline. HCl, it was neutralized with NaOH. Encapsulation efficiency of neutralized tetracycline was much higher (51.9-65.3%) due to the insoluble form of the drug used during encapsulation. The release behaviour of neither of the drugs was found to be of zero order. Rather the trends fitted reasonably well to Higuchi's approach for release from spherical micropheres. Biodegradability was not an appreciable parameter in the release from microcapsules because release was complete before any signs of degradation were observed.


Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Kavruk, M.; ÇELİKBIÇAK, ÖMÜR; Ozalp, V. C.; Borsa, B. A.; Hernandez, F. J.; BAYRAMOĞLU, GÜLAY; SALİH, BEKİR; ARICA, MEHMET YAKUP (2015-01-01)
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis
Gurses, Ozlem; Koc, Elcin Kartal (2014-04-01)
Purpose: The aim of this study is to compare the serum interleukin (IL) levels between the patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis. Methods: This is a prospective study involving 12 patients with extraocular manifestations of Behçet disease and 16 patients with Behçet disease-associated uveitis. The patients are involved in this study according to declaration of Helsinki. Inclusion criteria for all patients consist of a positive HLA B51 tissue typing...
Estimation of disease progression for ischemic heart disease using latent Markov with covariates
Oflaz, Zarina; Yozgatlıgil, Ceylan; Kestel, Sevtap Ayşe (2022-06-01)
Contemporaneous monitoring of disease progression, in addition to early diagnosis, is important for the treatment of patients with chronic conditions. Chronic disease-related factors are not easily tractable, and the existing data sets do not clearly reflect them, making diagnosis difficult. The primary issue is that databases maintained by health care, insurance, or governmental organizations typically do not contain clinical information and instead focus on patient appointments and demographic profiles. D...
Improving the Computer-Aided Estimation of Ulcerative Colitis Severity According to Mayo Endoscopic Score by Using Regression-Based Deep Learning
Polat, Gorkem; Kani, Haluk Tarik; Ergenc, Ilkay; Alahdab, Yesim Ozen; Temizel, Alptekin; Atug, Ozlen (2022-11-01)
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In vivo response to biodegradable controlled antibiotic release systems
Korkusuz, F; Korkusuz, P; Eksioglu, F; Gursel, I; Hasırcı, Vasıf Nejat (2001-05-01)
In this study, the major goal was to evaluate in vitro and in vivo findings by macroscopy, radiology, and histology to determine the effectiveness of therapy of experimental implant-related osteomyelitis with antibiotic carrier rods constructed of microbial polyesters. The polymers used were poly(3-hydroxybutyrate-co-4-hydroxyvalerate) [P(3HB-co-4-HB)] and poly(3-hydroxybutyrate-co-3-hydroxy-valerate) [P(3-HB-co-3-HV)]. Both the Sulperazone(R) and the Duocid(R)-P(3-HB-co-4-HB) rods with a drug to polymer ra...
Citation Formats
D. Sendil, I. Gursel, D. Wise, and V. N. Hasırcı, “Antibiotic release from biodegradable PHBV microparticles,” JOURNAL OF CONTROLLED RELEASE, pp. 207–217, 1999, Accessed: 00, 2020. [Online]. Available: