Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

Date

2015-01-01

Author

Kavruk, M.
ÇELİKBIÇAK, ÖMÜR
Ozalp, V. C.
Borsa, B. A.
Hernandez, F. J.
BAYRAMOĞLU, GÜLAY
SALİH, BEKİR
ARICA, MEHMET YAKUP

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In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

Subject Keywords

Mesoporous silica nanoparticles, Controlled-release, S aureus, Delivery, Vancomycin, DNA

URI

https://hdl.handle.net/11511/68492

Journal

CHEMICAL COMMUNICATIONS

DOI

https://doi.org/10.1039/c5cc01869b

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

M. Kavruk et al., “Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens,” CHEMICAL COMMUNICATIONS, pp. 8492–8495, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68492.