Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

Date

2015-01-01

Author

Kavruk, M.
ÇELİKBIÇAK, ÖMÜR
Ozalp, V. C.
Borsa, B. A.
Hernandez, F. J.
BAYRAMOĞLU, GÜLAY
SALİH, BEKİR
ARICA, MEHMET YAKUP

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

263
views

0
downloads

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

Subject Keywords

Mesoporous silica nanoparticles, Controlled-release, S aureus, Delivery, Vancomycin, DNA

URI

https://hdl.handle.net/11511/68492

Journal

CHEMICAL COMMUNICATIONS

DOI

https://doi.org/10.1039/c5cc01869b

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Antimicrobial aptamers for detection and inhibition of microbial pathogen growth Ozalp, Veli Cengiz; Bilecen, Kivanc; Kavruk, Murat; Öktem, Hüseyin Avni (Future Medicine Ltd, 2013-03-01) Discovery of alternative sources of antimicrobial agents are essential in the ongoing battle against microbial pathogens. Legislative and scientific challenges considerably hinder the discovery and use of new antimicrobial drugs, and new approaches are in urgent demand. On the other hand, rapid, specific and sensitive detection of airborne pathogens is becoming increasingly critical for public health. In this respect affinity oligonucleotides, aptamers, provide unique opportunities for the development of na...
MEMS biosensors for detection of methicillin resistant Staphylococcus aureus Ceylan Koydemir, Hatice; Külah, Haluk; Özgen, Canan; ALP, ALPASLAN; Hascelik, Gulsen (2011-11-15) This review presents the current state of the conventional methods, microfluidic based biosensors, and the commercial products used in the detection of methicillin resistant Staphylococcus aureus (MRSA), which is one of the most important threats of nosocomial infections in many parts of the world. The early detection of MRSA in the specimens of the patients is important to enable the appropriate treatment, to decrease morbidity and mortality rates, and to manage control actions in the healthcare units. Thu...
Antioxidant capacities of selected fruits and herbal teas consumed in regular diet and their antimicrobial activities against Staphylococcus aureus Barut, Burak; Çoruh, Nursen; Department of Biochemistry (2011) Staphylococcus aureus is one of the major causes of food-borne pathogenesis. Antibiotic consumption for these pathogens has been increasing year by year world-wide. In order to decrease the use of synthetic antibiotics, fresh fruits and dry herbs consumed as beverages in regular diets were examined as potential natural antibiotics for the treatment of food based infections against Staphylococcus aureus. Herbs consumed as tea infusions including Pimpinella anisum L. (anise), Anthemis arvensis L. (camomile), ...
Treatment of implant-related methicillin-resistant Staphylococcus aureus osteomyelitis with vancomycin-loaded VK100 silicone cement: An experimental study in rats Neyisci, Cagri; Erdem, Yusuf; Bilekli, Ahmet Burak; Demiralp, Bahtiyar; Kose, Ozkan; Bek, Dogan; Korkusuz, Feza; Kankilic, Berna (SAGE Publications, 2018-1) Introduction: The purpose of this present study is to investigate the efficacy of vancomycin-loaded VK100 silicone cement drug delivery system in the treatment of implant-related methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis in rats. Materials and Methods: Thirty-six adult (18-20 weeks old) female Sprague-Dawley rats were included in the study. All rats underwent experimental osteomyelitis surgery via injecting 100 mu L bacterial suspension of MRSA into the medullary canal. After a 2-week...
Immunotherapeutic applications of CpG-containing oligodeoxynucleotides Klinman, DM; Ishii, KJ; Gürsel, Mayda; Gursel, I; Takeshita, S; Takeshita, F (2000-06-01) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines. CpG ODN directly stimulate lymphocytes, natural killer cells and professional antigen-presenting cells (such as macrophages and dendritic cells). Owing to the strength and nature of this stimulation, CpG ODN are being harnessed f...

Citation Formats

M. Kavruk et al., “Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens,” CHEMICAL COMMUNICATIONS, pp. 8492–8495, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68492.