Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis

Date

2014-04-01

Author

Gurses, Ozlem
Koc, Elcin Kartal

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

117
views

0
downloads

Purpose: The aim of this study is to compare the serum interleukin (IL) levels between the patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis. Methods: This is a prospective study involving 12 patients with extraocular manifestations of Behçet disease and 16 patients with Behçet disease-associated uveitis. The patients are involved in this study according to declaration of Helsinki. Inclusion criteria for all patients consist of a positive HLA B51 tissue typing and without receiving any immunosuppressive or immunomodulatory therapy for at least 6 months. The serum levels of IL-23, IL-21, IL-17,IL-10, and IL-6 were analyzed with enzyme-linked immunosorbent assay. Statistical analysis were performed with 2-sample t-test and Mann Whitney test. Results: There were no statistically significant differences of IL-17,Il-21,IL-10 and Il-6 serum levels between patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis.(p = 0.954 > 0.05, p = 0.147 > 0.05, p = 0.227 > 0.05, p = 0.133 > 0.05 respectively) Serum IL-23 levels of patients with Behçet disease-associated uveitis were significantly elevated as compared to the patients with extraocular manifestations of Behçet disease. (p = 0.025 < 0.05) Conclusions: Increased serum levels of IL-23 in patients with Behçet disease-associated uveitis may be related to intraocular inflammation and it may play a critical role in the pathogenesis of Behçet disease-associated uveitis.

Subject Keywords

557 Inflammation , 746 Uveitis-Clinical/Animal Model, 702 Retinitis

URI

https://hdl.handle.net/11511/65339

Journal

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Collections

Unclassified, Article

Suggestions

OpenMETU
Core

The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of ankylosing spondylitis, behcet disease, sarcoidosis and latent tuberculosis Gurses, Ozlem; Karaismailoglu, Eda (2013-06-01) Purpose: To evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels between the patient groups. Methods: This is a prospective study involving 37 patients with HLAB27+ ankylosing spondylitis, 47 patients with HLAB51+ behcet disease, 29 patients with sarcoidosis and 27 patients with quantiferon+ latent tuberculosis. The patients are included in the study according to the tenets of Decleration of Helsinki. The serum levels of angiotensin converting enzyme and lysoz...
Association of-174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients Mutlu, Pelin; Elci, Pinar; Yildirim, Murat; Cetin, A. Turker; Avcu, Ferit (2014-07-01) Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients.
Improving the Computer-Aided Estimation of Ulcerative Colitis Severity According to Mayo Endoscopic Score by Using Regression-Based Deep Learning Polat, Gorkem; Kani, Haluk Tarik; Ergenc, Ilkay; Alahdab, Yesim Ozen; Temizel, Alptekin; Atug, Ozlen (2022-11-01) Background Assessment of endoscopic activity in ulcerative colitis (UC) is important for treatment decisions and monitoring disease progress. However, substantial inter- and intraobserver variability in grading impairs the assessment. Our aim was to develop a computer-aided diagnosis system using deep learning to reduce subjectivity and improve the reliability of the assessment. Methods The cohort comprises 11 276 images from 564 patients who underwent colonoscopy for UC. We propose a regression-based deep ...
Recombinant therapeutic protease production by Bacillus sp. Korkmaz, Nuriye; Çalık, Pınar; Department of Chemical Engineering (2007) The first aim of this study is the development of extracellular recombinant therapeutic protease streptokinase producing Bacillus sp., and the second aim is to determine fermentation characteristics for streptokinase production. In this context, the signal (pre-) DNA sequence of B.licheniformis (DSM1969) extracellular serine alkaline protease enzyme gene (subC: Acc. No. X03341) was ligated to 5’ end of the streptokinase gene (skc: Acc. No. S46536) by SOE (Gene Splicing by Overlap Extension) method through P...
The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases Sahin, Ozlem; Ziaei, Alireza; Karaismailoğlu, Eda; Taheri, Nusret (Springer Science and Business Media LLC, 2016-2-16) Background: Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases. Methods: This is a prospective study involving patients with ankylosing spondylitis, behc...

Citation Formats

O. Gurses and E. K. Koc, “Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis,” INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, pp. 0–0, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/65339.