MEMS biosensors for detection of methicillin resistant Staphylococcus aureus

Ceylan Koydemir, Hatice
Külah, Haluk
Özgen, Canan
Hascelik, Gulsen
This review presents the current state of the conventional methods, microfluidic based biosensors, and the commercial products used in the detection of methicillin resistant Staphylococcus aureus (MRSA), which is one of the most important threats of nosocomial infections in many parts of the world. The early detection of MRSA in the specimens of the patients is important to enable the appropriate treatment, to decrease morbidity and mortality rates, and to manage control actions in the healthcare units. Thus, rapid and inexpensive diagnostic systems with high sensitivity and specificity are essential to prevent MRSA to be an emerging public health threat. The design and fabrication of new diagnostic systems necessitates working in collaboration between different disciplines to make new challenges in the field of clinical diagnosis and to meet the demands of clinicians. It is certain that in the near future. MEMS and nanotechnology based detection methods will take the place of current methods in clinical diagnosis. The evaluation of new trends for specificity, sensitivity, cost effectiveness, disposability, low weight, ease of use, and facile access should be taken into consideration.


MEMS based electrochemical DNA sensor to detect methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus species
Ceylan Koydemir, Hatice; Özgen, Canan; Külah, Haluk; Department of Chemical Engineering (2013)
Methicillin Resistant Staphylococcus aureus (MRSA) is one of the most important threats of nosocomial infections in many regions of the world and Vancomycin Resistant Enterococcus (VRE) is an emerging pathogen that develops full resistance against third-generation glycopeptide antibiotics. Conventional methods for identification of MRSA and VRE generally depend on culturing, which requires incubation of biological samples at least 24-72 hours to get accurate results. These methods are time consuming and nec...
Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Kavruk, M.; ÇELİKBIÇAK, ÖMÜR; Ozalp, V. C.; Borsa, B. A.; Hernandez, F. J.; BAYRAMOĞLU, GÜLAY; SALİH, BEKİR; ARICA, MEHMET YAKUP (2015-01-01)
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
Antioxidant capacities of selected fruits and herbal teas consumed in regular diet and their antimicrobial activities against Staphylococcus aureus
Barut, Burak; Çoruh, Nursen; Department of Biochemistry (2011)
Staphylococcus aureus is one of the major causes of food-borne pathogenesis. Antibiotic consumption for these pathogens has been increasing year by year world-wide. In order to decrease the use of synthetic antibiotics, fresh fruits and dry herbs consumed as beverages in regular diets were examined as potential natural antibiotics for the treatment of food based infections against Staphylococcus aureus. Herbs consumed as tea infusions including Pimpinella anisum L. (anise), Anthemis arvensis L. (camomile), ...
Treatment of implant-related methicillin-resistant Staphylococcus aureus osteomyelitis with vancomycin-loaded VK100 silicone cement: An experimental study in rats
Neyisci, Cagri; Erdem, Yusuf; Bilekli, Ahmet Burak; Demiralp, Bahtiyar; Kose, Ozkan; Bek, Dogan; Korkusuz, Feza; Kankilic, Berna (SAGE Publications, 2018-1)
Introduction: The purpose of this present study is to investigate the efficacy of vancomycin-loaded VK100 silicone cement drug delivery system in the treatment of implant-related methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis in rats. Materials and Methods: Thirty-six adult (18-20 weeks old) female Sprague-Dawley rats were included in the study. All rats underwent experimental osteomyelitis surgery via injecting 100 mu L bacterial suspension of MRSA into the medullary canal. After a 2-week...
Characterization and genomic analysis of a novel bacteriophage against methicillin-resistant staphylococcus aureus
Çotak, Medine; Akkaya, Mahinur S.; Karahan, Zeynep Ceren; Department of Biotechnology (2019)
Methicillin resistant Staphylococcus aureus (MRSA) is one of the most frequent hospital and community acquired infectious agents causing severe diseases. Bacteriophages may offer a solution to treat the bacterial infections that are not responding to classical antibiotics. In this context, a new lytic phage, named as vB_SauM-MikSA913, was isolated from sewage treatment center in Samsun (Turkey). MRSA clinical strains obtained from a local hospital were used as propagating hosts while searching for the lytic...
Citation Formats
H. Ceylan Koydemir, H. Külah, C. Özgen, A. ALP, and G. Hascelik, “MEMS biosensors for detection of methicillin resistant Staphylococcus aureus,” BIOSENSORS & BIOELECTRONICS, pp. 1–12, 2011, Accessed: 00, 2020. [Online]. Available: