Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats

Date

2010-01-01

Author

Bingol-Kologlu, Meltem
Bahadir, G. Berktug
Vargun, Rahsan
Ilkay, Hande
Bagriacik, E. Umit
Yolbakan, Sultan
Guven, Cengiz
Endogan, Tugba
Hasırcı, Nesrin
Dindar, Huseyin

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

143
views

0
downloads

OBJECTIVES To evaluate the effects of the local release of fibroblast growth factor (FGF), insulin-like growth factor (IGF), and growth hormone (GH) on a germ cell population of ipsilateral undescended and contralateral descended testes of rats with a surgically created unilateral abdominal testis for 12 weeks and after the application of growth factors after orchidopexy.

Subject Keywords

Hormone, Spermatogenesis, Insulin, Leydig-cells, Sertoli-cells, Cryptorchid testis, Testicular function, Factor-i, DNA flow-cytometry, Fibroblast-growth-factor

URI

https://hdl.handle.net/11511/31065

Journal

UROLOGY

DOI

https://doi.org/10.1016/j.urology.2009.04.017

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Effect of double growth factor release on cartilage tissue engineering Ertan, Ayse Burcu; Yilgor, Pinar; Bayyurt, Banu; Calikoglu, Ayse Ceren; Kaspar, Cigdem; Kök, Fatma Neşe; KÖSE, GAMZE; Hasırcı, Vasıf Nejat (2013-02-01) The effects of double release of insulin-like growth factor I (IGF-I) and growth factor 1 (TGF1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were studied on PLGA scaffolds. The release was achieved by using nanoparticles of poly(lactic acid-co-glycolic acid) (PLGA) and poly(N-isopropylacrylamide) (PNIPAM) carrying IGF-I and TGF1, respectively. On tissue culture polystyrene (TCPS), TGF-1 released from PNIPAM nanoparticles was found to ...
Effects of ph on human growth hormone production by pichia pastoris considering the expression levels of regulatory genes Bayraktar, Eda; Çalık, Pınar; Department of Chemical Engineering (2009) In this study, the aim was to investigate the effects of pH on therapeutically important protein, recombinant human growth hormone (rhGH), production by Pichia pastoris considering the expression levels of regulatory genes. In this frame, firstly the host microorganism was selected between two different methanol utilization phenotypes of P. pastoris, Mut+ and MutS on media containing glycerol/methanol or sorbitol/methanol. The highest rhGH production, 120 g L-1, and hGH gene expression, 9.84x109 copies mg-1...
The effects of local and sustained release of fibroblast growth factor on testicular blood flow and morphology in spermatic artery- and vein-ligated rats Guler, F; Bingol-Kologlu, MB; Yagmurlu, A; Guven, C; Hasırcı, Nesrin; Kucuk, O; Aytac, S; Dindar, H (2004-05-01) Background/Purpose: This study was carried out to evaluate the effects of local and sustained release of fibroblast growth factor (FGF) on testicular blood flow and morphology in spermatic artery- and vein-ligated rats.
The Effects of Local and Systemic Growth Hormone Treatment on Germ Cell Population and Fertility in an Experimental Unilateral Testicular Torsion and Orchiectomy Model ATEŞ, UFUK; Gollu, Gulnur; Bingol-Kologlu, Meltem; BİLLUR, DENİZ; Kucuk, Gonul; Oruklu, Nihan; Bagriacik, Umit; Hasırcı, Nesrin; DİNDAR, HÜSEYİN (2015-12-01) Purpose: We evaluated the effects of local and systemic growth hormone on the germ cell population of the contralateral testes of pubertal rats subjected to unilateral testicular torsion and orchiectomy 24 hours later.
Effects of carbon sources and feeding strategies on human growth hormone production by metabolically engineered pichia pastoris Açık, Eda; Çalık, Pınar; Department of Chemical Engineering (2009) In this study, effects of different carbon sources and their feeding strategies on recombinant human growth hormone (rhGH) production by Pichia pastoris were investigated by means of cell growth, recombinant protein production and expression levels of hGH and alcohol oxidase (AOX) genes. In this content, firstly, the strain to be used for high level rhGH production was selected between the two phenotypes, i.e., P. pastoris hGH-Mut+ and P. pastoris hGH-MutS. In this selection both phenotypes were compared in...

Citation Formats

M. Bingol-Kologlu et al., “Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats,” UROLOGY, pp. 223–228, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31065.