In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration

Date

2020-12-01

Author

Tombuloğlu, Ayşegül
Çöpoğlu, Hülya
Aydın Son, Yeşim
Güray, Nülüfer Tülün

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Boron is a prominent part of the human diet and one of the essential trace elements for humans. Dietary boron is mostly transformed into boric acid within the body and has been associated with desirable health outcomes. Non-dietary resources of boron, such as boron-based drugs and occupational exposure, might lead to excessive boron levels in the blood and provoke health adversities. The liver might be particularly sensitive to boron intake with ample evidence suggesting a relation between boron and liver function, although the underlying molecular processes remain largely unknown.

Subject Keywords

Boric acid, IC50, Cytotoxicity, DNA damage, Microarray, HepG2

URI

https://hdl.handle.net/11511/31208

Collections

Graduate School of Informatics, Article