In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration

Date

2020-12-01

Author

Tombuloğlu, Ayşegül
Çöpoğlu, Hülya
Aydın Son, Yeşim
Güray, Nülüfer Tülün

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

256
views

0
downloads

Boron is a prominent part of the human diet and one of the essential trace elements for humans. Dietary boron is mostly transformed into boric acid within the body and has been associated with desirable health outcomes. Non-dietary resources of boron, such as boron-based drugs and occupational exposure, might lead to excessive boron levels in the blood and provoke health adversities. The liver might be particularly sensitive to boron intake with ample evidence suggesting a relation between boron and liver function, although the underlying molecular processes remain largely unknown.

Subject Keywords

Boric acid, IC50, Cytotoxicity, DNA damage, Microarray, HepG2

URI

https://hdl.handle.net/11511/31208

Journal

Journal Of Trace Elements In Medicine And Biology

DOI

https://doi.org/10.1016/j.jtemb.2020.126573

Collections

Graduate School of Informatics, Article

Suggestions

OpenMETU
Core

In vitro starch digestion of flat dough pieces with and without fiber Güler, Nilay; Şensoy, İlkay; Department of Food Engineering (2022-2-09) The digestive behavior of starch, which supplies most of our daily energy needs, is vital for health. Starch-rich foods that provoke a high glycemic response are alterable risk factors for obesity, type-2 diabetes, and cardiovascular disease. Therefore, it is crucial to promote staple foods that provide a controlled glucose release in the blood. Incorporating different cooking methods and dietary fiber into regularly eaten products is a food design strategy that leads to several advantages to decrease chron...
Developmental selenium exposure and health risk in daily foodstuffs: A systematic review and meta-analysis Ullah, Habib; Liu, Guijian; Yousaf, Balal; Ali, Muhammad Ubaid; Abbas, Qumber; Munir, Mehr Ahmed Mujtaba; Mian, Md Manik (2018-03-01) Selenium (Se) is a trace mineral and an essential nutrient of vital importance to human health in trace amounts. It acts as an antioxidant in both humans and animals, immunomodulator and also involved in the control of specific endocrine pathways. The aim of this work is to provide a brief knowledge on selenium content in daily used various foodstuffs, nutritional requirement and its various health consequences. In general, fruits and vegetables contain low content of selenium, with some exceptions. Seleniu...
A biomechanical and spectroscopic study of bone from rats with selenium deficiency and toxicity Turan, B; Bayari, S; Balcik, C; Severcan, Feride; Akkas, N (2000-06-01) Selenium, being an essential mineral in the mammalian diet, is important in providing protection against oxidative damage. Numerous in vitro studies of selenium compounds reveal a very high correlation between catalytic activity of selenium compounds and toxicity. The present study was designed to investigate the effects of dietary selenium on the biomechanical properties of bone. New born rats of both sexes were fed with either a control, or a selenium- and vitamin E-deficient, or a selenium-excess and vit...
MODULATION OF CYTOCHROME P450s AND ANTIOXIDANT ENZYMES BY CAFFEIC ACID, p-COUMARIC ACID AND QUERCETIN-RICH ANATOLIAN PROPOLIS IN HUMAN ADENOCARCINOMA HT-29 CELLS ALTAY, AHMET; İrtem Kartal, Deniz; Sagdicoglu-Celep, Gulcin; Güray, Nülüfer Tülün; Bozoglu, Faruk (2018-01-01) Propolis, which is a complex resinous material has diverse pharmacological and biological properties. Phase I and II enzymes are responsible for detoxication and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in metabolic activation of xenobiotics. This study was designed to investigate the in vitro modulatory effects of Anatolian propolis and its phenolic contents; caffeic acid, quercetin and p-coumaric acid on t...
Changes in gene profile of human hepatocellular carcinoma cell line (HepG2) induced by boric acid at half mazimal inhibitory concentration (IC50). Tombuloğlu, Ayşegül; Çöpoğlu, Hülya; Güray, Nülüfer Tülün; Aydın Son, Yeşim (null; 2017-06-30) Boron is an essential micronutrient for many biological processes in plants and animals. In humans, adverse health outcomes are reported for both boron deprivation and excessive boron intake. Humans might get exposed to high doses of boron by consuming boron containing products or by working at boron enriched workplaces. In this study, the aim is to find out about the cytotoxicity mechanisms of boric acid, the most abundant form of boron containing compounds in human blood, on human hepatocellular carcinoma...

Citation Formats

A. Tombuloğlu, H. Çöpoğlu, Y. Aydın Son, and N. T. Güray, “In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration,” Journal Of Trace Elements In Medicine And Biology, pp. 126–130, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31208.