Chitosan-based wet-spun scaffolds for bioactive agent delivery

Date

2013-12-05

Author

Ucar, Seniz
Yilgor, Pinar
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin

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Use of scaffolds both as supporting materials at defect site and delivery vehicles for bioactive agents is a commonly employed strategy to aid in tissue repair and regeneration. In this study, fibrous meshes of chitosan were prepared by wet spinning and coated with alginate. BSA as a model protein and gentamicin as a model antibiotic were incorporated into the scaffolds in multiple loading models and their release kinetics were studied. The effects of structural form of scaffold and properties of bioactive agents on release profiles were evaluated. Our results suggest that, designed scaffolds are potential candidates for tissue engineering with the feature of controlled bioactive agent delivery. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3759-3769, 2013

Subject Keywords

Biomaterials, Drug Delivery Systems, Polysaccharides, Structure-Property Relations

URI

https://hdl.handle.net/11511/31444

Journal

JOURNAL OF APPLIED POLYMER SCIENCE

DOI

https://doi.org/10.1002/app.39629

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

S. Ucar, P. Yilgor, V. N. Hasırcı, and N. Hasırcı, “Chitosan-based wet-spun scaffolds for bioactive agent delivery,” JOURNAL OF APPLIED POLYMER SCIENCE, pp. 3759–3769, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31444.