Poly(epsilon-caprolactone) composites containing gentamicin-loaded beta-tricalcium phosphate/gelatin microspheres as bone tissue supports

Date

2013-02-05

Author

Sezer, Umran Aydemir
Aksoy, Eda Ayse
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

188
views

0
downloads

In this work, novel antibacterial composites were prepared by using poly(epsilon-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of beta-tricalcium phosphate (beta-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of beta-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. The effects of the ratio of the beta-TCP/gelatin microspheres on the morphological, mechanical, and degradation properties of composite films as well as in vitro antibiotic release and antibacterial activities against Escherichia coli and Staphylococcus aureus were investigated. The results showed that the composites of PCL and beta-TCP/gelatin microspheres had antibacterial activities for both bacteria. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Subject Keywords

Poly(Epsilon-Caprolactone), Beta-Tricalcium Phosphate, Gelatin, Fillers, Biodegradable, Controlled Release, Antibacterial Activity

URI

https://hdl.handle.net/11511/31548

Journal

JOURNAL OF APPLIED POLYMER SCIENCE

DOI

https://doi.org/10.1002/app.37770

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Poly(epsilon-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing beta-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications Sezer, Umran Aydemir; Arslantunalı Şahin, Damla; Aksoy, Eda Ayse; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-04-15) In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in th...
Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) based tissue engineering matrices Kose, GT; Ber, S; Korkusuz, Feza; Hasırcı, Vasıf Nejat (2003-02-01) In this study, the aim was to produce tissue-engineered bone using osteoblasts and a novel matrix material, poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV). In order to prepare a porous PHBV matrix with uniform pore size, sucrose crystals were loaded in the foam and then leached leaving pores behind. The surface of the PHBV matrix was treated with rf-oxygen plasma to increase the surface hydrophilicity. SEM examination of the PHBV matrices was carried out. Stability of PHBV foams in aqueous medi...
Poly(methyl methacrylate) nanocomposites involving aromatic diboronic acid Goktas, Muberra; Hacaloğlu, Jale (2019-12-01) In this work, poly(methyl methacrylate), PMMA, composites involving various amounts of aromatic diboronic acid, BDBA, in the absence and presence of organically modified montmorillonite, Cloisite 30B, C30B, were prepared and characterized by X-ray diffraction, transmission electron microscopy, thermogravimetry, and direct pyrolysis mass spectrometry analyses. Morphologic analyses indicated homogenous dispersion of additives in PMMA matrix. Increase in thermal stability of PMMA was observed as the amount of ...
Facile synthesis of CsPbBr3/PbSe composite clusters Thang Phan Nguyen, Thang Phan Nguyen; Öztürk, Abdullah; PARK, JONGEE; Sohn, Woonbae; Tae Hyung Lee, Tae Hyung Lee; Jang, Ho Won; Kim, Soo Young (Informa UK Limited, 2018-12-18) In this work, CsPbBr3 and PbSe nanocomposites were synthesized to protect perovskite material from self-enlargement during reaction. UV absorption and photoluminescence (PL) spectra indicate that the addition of Se into CsPbBr3 quantum dots modified the electronic structure of CsPbBr3, increasing the band gap from 2.38 to 2.48 eV as the Cs:Se ratio increased to 1:3. Thus, the emission color of CsPbBr3 perovskite quantum dots was modified from green to blue by increasing the Se ratio in composites. According...
Pyrolysis of poly(phenylene vinylene)s with polycaprolactone side chains Nur, Yusuf; Çolak, Demet; Cianga, Ioan; Yagci, Yusuf; Hacaloğlu, Jale (2008-05-01) The thermal degradation characteristics of a new macromonomer poly(epsilon-caprolactone) with central 4,4'-dicarbaldehyde terphenyl moieties and poly(phenylene vinylene)s with well defined (E-caprolactone), (PPV/PCL) as lateral substituents were investigated via direct pyrolysis mass spectrometry. The unexpectedly high thermal stability of the macromonomer was attributed to intermolecular acetylation of benzaldehyde yielding a hemiacetal and causing a crosslinked structure during the pyrolysis. Increased th...

Citation Formats

U. A. Sezer, E. A. Aksoy, V. N. Hasırcı, and N. Hasırcı, “Poly(epsilon-caprolactone) composites containing gentamicin-loaded beta-tricalcium phosphate/gelatin microspheres as bone tissue supports,” JOURNAL OF APPLIED POLYMER SCIENCE, pp. 2132–2139, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31548.