Poly(epsilon-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing beta-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications

Date

2014-04-15

Author

Sezer, Umran Aydemir
Arslantunalı Şahin, Damla
Aksoy, Eda Ayse
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin

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In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos-2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110.

Subject Keywords

Biodegradable, Biomaterials, Composites, Foams

URI

https://hdl.handle.net/11511/32449

Journal

JOURNAL OF APPLIED POLYMER SCIENCE

DOI

https://doi.org/10.1002/app.40110

Collections

Graduate School of Natural and Applied Sciences, Article

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Poly(epsilon-caprolactone) composites containing gentamicin-loaded beta-tricalcium phosphate/gelatin microspheres as bone tissue supports Sezer, Umran Aydemir; Aksoy, Eda Ayse; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2013-02-05) In this work, novel antibacterial composites were prepared by using poly(epsilon-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of beta-tricalcium phosphate (beta-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of beta-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. Th...
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Citation Formats

U. A. Sezer, D. Arslantunalı Şahin, E. A. Aksoy, V. N. Hasırcı, and N. Hasırcı, “Poly(epsilon-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing beta-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications,” JOURNAL OF APPLIED POLYMER SCIENCE, pp. 0–0, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32449.