Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations

Hirschmann, Jan
Butz, Markus
Hartmann, Christian J.
Hoogenboom, Nienke
Özkurt, Tolga Esat
Vesper, Jan
Wojtecki, Lars
Schnitzler, Alfons
BackgroundHigh frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement.


Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2013-03-01)
Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease
Hirschmann, Jan; Hartmann, Christian J.; Butz, Markus; Hoogenboom, Nienke; Özkurt, Tolga Esat; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2013-12-01)
Electrophysiological studies suggest that rest tremor in Parkinson's disease is associated with an alteration of oscillatory activity. Although it is well known that tremor depends on cortico-muscular coupling, it is unclear whether synchronization within and between brain areas is specifically related to the presence and severity of tremor. To tackle this longstanding issue, we took advantage of naturally occurring spontaneous tremor fluctuations and investigated cerebral synchronization in the presence an...
Theoretical investigation of effects of flow oscillations on ultrasound Doppler velocity measurements
Koseli, Volkan; Uludağ, Yusuf (Elsevier BV, 2012-02-01)
Effects of flow oscillations on spectrum of Ultrasound Doppler Velocimetry (UDV) signals were investigated theoretically and numerically. A laminar pipe flow with a superimposed oscillating component was considered. Negative impact of oscillation on the ultrasound signal hence on the flow images was observed in the form of spreading of spectral ultrasound signal energy around mean component, leading to image artifacts. Both analytical and numerical results revealed the strong effect of a group of parameters...
Acute effects of local vibration on muscle performance at different durations and frequencies
Yıldırım, Ahmet; Korkusuz, Feza; Department of Physical Education and Sports (2010)
The purpose of the present study was to investigate the acute effects of local vibration on muscle performance at different durations and frequencies. Fifteen male handball players participated in the study voluntarily. University’s Ethics Committee approved the study and the informed consent forms were filled by all participants. Different vibration durations, (10 sec, 1 min, 10 min), different frequencies (40 and 80 Hz), dominancy (dominant and non-dominant) and conditions (vibration and no-vibration) wer...
Computational analysis of network activity and spatial reach of sharp wave-ripples
Canakci, Sadullah; Toy, Muhammed Faruk; Inci, Ahmet Fatih; Liu, Xin; Kuzum, Duygu (Public Library of Science (PLoS), 2017-9-15)
Network oscillations of different frequencies, durations and amplitudes are hypothesized to coordinate information processing and transfer across brain areas. Among these oscillations, hippocampal sharp wave-ripple complexes (SPW-Rs) are one of the most prominent. SPW-Rs occurring in the hippocampus are suggested to play essential roles in memory consolidation as well as information transfer to the neocortex. To-date, most of the knowledge about SPW-Rs comes from experimental studies averaging responses fro...
Citation Formats
J. Hirschmann et al., “Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations,” MOVEMENT DISORDERS, pp. 1551–1559, 2016, Accessed: 00, 2020. [Online]. Available: