Polyethylene oxide-hydroxyapatite composite and microporous polyethylene oxide-polymethacrylic acid polymer complex preparation and characterization

Banat, Raid M I
The first part of this study covers the crosslinking of polyethylene oxide (PEO) and its composite with calcium hydroxyapatite (HA) and their mechanical, swelling and morphological properties. Sheets of neat PEO (two different molecular weights) and composites of PEO-HA were prepared by compression molding. The composites and PEO thick sheets were crosslinked with exposure of UV- irradiation in presence of acetophenone (AP) for different periods of time. This simple method of crosslinking, UV-irradiation induced crosslinking in the presence of acetophenone, yielded PEO with gel content up to 90%. Gel content, equilibrium swelling ratio, mechanical and morphological properties of the low molecular weight polyethylene oxide LMPEO-HA composites of crosslinked and uncrosslinked were evaluated. Although the inclusion of HA into LMPEO inhibited the extent of crosslinking, LMPEO- III(20%)HA composite showed the highest gel content with appreciable equilibrium swelling and mechanical strength. The growth of HA from simulated body fluid solutions on fractured surfaces of LMPEO and LMPEO-HA was found to be very favourable in short times. The dimensional stability of these samples is found to be good enough after swelling and deposition experiments. Good compatibility between the hydroxyapatite and PEO can be regarded to be useful tissue-adhesive material. In the second part of this study a microporous polymer complex of polymethacrylic acid (PMAA)-polyethylene oxide was prepared and characterized. Microporous polymer complex of PMAA-PEO was obtained by solution polymerization using benzoyl peroxide as the initiator. PEO (Mv; 200,000) and methacrylic acid monomer mixture produced a microporous polymer complex with a scaffold strength. The polymer complex of PMAA- PEO was partially water soluble. To overcome the solubility of the water- soluble microporous polymer complex; chemical crosslinking was carried out by using ethlyleneglycol dimethacrylate monomer (EGDMA) as the crosslinking agent. Depending upon the extent of crosslinking process PMAA-PEO became water insoluble but it could swell in aqueous solution without any rupture. Thermal stability of the prepared crosslinked and uncrosslinked microporous polymer complex of PMAA-PEO was examined by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Compressive mechanical properties were also examined.


Study on the properties of crosslinking of poly(ethylene oxide) and hydroxyapatite-poly(ethylene oxide) composite
Banat, R; Tincer, T (2003-10-10)
This study covers the crosslinking of poly-(ethylene oxide) (PEO) and its composite with calcium hydroxyapatite (HA), their mechanical and swelling properties, and morphology. Sheets of the composites of PEO (two different grades with M-v: 5x10(6) and 2x10(5)) and HA and neat PEO were prepared by compression molding. The prepared composite. and. PEO (0.1-mm-thick) sheets were crosslinked with exposure of UV-irradiation in the presence of a photoinitiator, acetophenone (AP). This simple method for crosslinki...
Pyrolysis mass spectrometric analysis of copolymer of polyacrylonitrile and polythiophene
Oğuz, Gülcan; Hacaloğlu, Jale; Department of Polymer Science and Technology (2004)
In the first part of this work, the structural and thermal characteristics of polyacrylonitrile, polyacrylonitrile films treated under the electrolysis conditions in the absence of thiophene, polythiophene and the mechanical mixture and a conducting copolymer of polyacrylonitrile/polythiophene have been studied by pyrolysis mass spectrometry technique. The thermal degradation of polyacrylonitrile occurs in three steps; evolution of HCN, monomer, low molecular weight oligomers due to random chain cleavages a...
Facile control of hydroxyapatite particle morphology by utilization of calcium carbonate templates at room temperature
Oral, Çağatay M.; Çalışkan, Arda; Kapusuz, Derya; Ercan, Batur (Elsevier BV, 2020-09-01)
Hydroxyapatite (HAp, Ca-10(PO4)(6)(OH)(2)) particles are widely used in orthopedic applications due to their chemical resemblance to the inorganic component of bone tissue. Since physical and chemical properties of HAp particles influence bone regeneration, various synthesis techniques were developed to precisely control the particle properties. However, most of these techniques required high reaction temperatures, which limited the spectrum of obtained HAp particle morphologies. In this study, ellipsoidal,...
Nanocomposites based on blends of polyethylene
Işık, Fatma; Yılmazer, Ülkü; Department of Chemical Engineering (2005)
In this study the effects of compatibilizer type, organoclay type, and the addition order of components on the morphological, thermal, mechanical and flow properties of ternary nanocomposites based on low density polyethylene, LDPE were investigated. As compatibilizer, ethylene/methyl acrylate/glycidyl methacrylate, ethylene/glycidyl methacrylate, and ethylene/butyl acrylate/maleic anhydride; as organoclay Cloisite? 15A, Cloisite? 25A and Cloisite? 30B were used. All samples were prepared by a co-rotating t...
Poly(epsilon-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing beta-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications
Sezer, Umran Aydemir; Arslantunalı Şahin, Damla; Aksoy, Eda Ayse; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-04-15)
In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in th...
Citation Formats
R. M. I. Banat, “Polyethylene oxide-hydroxyapatite composite and microporous polyethylene oxide-polymethacrylic acid polymer complex preparation and characterization,” Ph.D. - Doctoral Program, Middle East Technical University, 2002.