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Characterization of β-cyclodextrin modified SiO2

2011-05-01
Nielsen, Ronnie
Kingshott, Peter
Uyar, Tamer
Hacaloğlu, Jale
Larsen, Kim L.
Silica particles containing a layer of beta-cyclodextrins were synthesized using a modified method of Armstrong (1985). The modified silica particles were extensively characterized to both the presence and amount of beta-cyclodextrin introduced onto the surface. Raman confirmed that beta-cyclodextrin was introduced onto the particle. The combination of thermogravmetric analysis (TGA) and direct pyrolysis mass spectroscopy were used to determine the amount and the chemical composition of organic material present on the silica, respectively. The two methods confirmed that beta-cyclodextrin was successfully introduced in amounts comparable to earlier literature values. The values obtained by TGA were compared to amounts found by elemental analysis and XPS. The elemental analysis and TGA found the same amount of beta-cyclodextrin, while the XPS values were in the region of 1.5 times higher. This suggests a heterogeneous distribution of the beta-cyclodextrin on the silica particles.