A Monostyryl Boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe for sequential sensing of copper (II) ions and dipicolinic acid as a biomarker of bacterial endospores

Date

2019-09-05

Author

Cetinkaya, Yagmur
Yurt, Mediha Nur Zafer
Öktem, Hüseyin Avni
Yilmaz, M. Deniz

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A new catechol-substituted monostyryl boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe was developed for the sequential detection of Cu2+ ions and dipicolinic acid (DPA), a distinctive biomarker of bacterial endospores, with high sensitivity and selectivity. In the presence of Cu2+ ions, the blue solution of the probe changes to cyan and the fluorescence is quenched, however, the cyan color changes to blue immediately and the fluorescence is restored on contact with DPA, resulting from competitive binding of DPA that interact with Cu2+ ions. A practical application by using Geobacillus stearothermophilus spores was further studied and as low as 1.0 x 10(5) spores were detected.

Subject Keywords

Bacterial endospores, Dipicolinic acid, BODIPY, Copper complex, Ratiometric detection

URI

https://hdl.handle.net/11511/32898

Journal

JOURNAL OF HAZARDOUS MATERIALS

DOI

https://doi.org/10.1016/j.jhazmat.2019.05.108

Collections

Department of Biology, Article

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Citation Formats

Y. Cetinkaya, M. N. Z. Yurt, H. A. Öktem, and M. D. Yilmaz, “A Monostyryl Boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe for sequential sensing of copper (II) ions and dipicolinic acid as a biomarker of bacterial endospores,” JOURNAL OF HAZARDOUS MATERIALS, pp. 299–304, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32898.