Surface Characterization and Biocompatibility of Selenium-Doped Hydroxyapatite Coating on Titanium Alloy

Selenium-doped hydroxyapatite (HA) was biomimetically coated on Ti6Al4V plates with the aim of combining the anticancer and antibacterial properties of selenium with the biocompatibility and bioactivity of HA. For the coating process, the composition of 1.5 x SBF (solution with ion concentrations at 1.5 times that of simulated body fluid, SBF) was modified to include 0.15 mM selenate (SeO42-) ion. The selenium-doped HA coating was characterized by several methods, such as scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. The cytotoxicity of selenium on osteoblast and osteosarcoma cells was determined. The coating was shown to inhibit the growth of Staphylococcus epidermidis.


Covalent immobilization of invertase on chemically activated poly(2-hydroxyethyl methacrylate) microbeads
Altinok, H.; Aksoy, S.; Tumturk, H.; Hasırcı, Nesrin (2006-10-01)
Properties of invertase immobilized on poly(2-hydroxyethyl methacrylate) microbeads activated by epichlorohydrin or cyanuric chloride were studied. After 20 repeated uses for 3 days, the activity of the immobilized enzyme was 92-93%.
Speciation of Selenium in Supplements by High Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometry
BAKIRDERE, Sezgin; Volkan, Mürvet; Ataman, Osman Yavuz (2015-06-13)
Anion and cation exchange high-performance liquid chromatography (HPLC) combined with inductively coupled plasma-mass spectrometry (ICP-MS) were used for speciation of selenium in supplements. All the parameters in the extraction, separation, and determination procedures were optimized. Recovery studies for the selenium species from the anion and cation exchange columns were performed and there were no analyte losses. Limits of detection for selenium(IV), selenium(VI), Se in selenomethionine, and Se in sele...
Thermal evolution of structure and photocatalytic activity in polymer microsphere templated TiO2 microbowls
Altunöz Erdoğan, Deniz; Polat, Meryem; Garifullin, Ruslan; Guler, Mustafa O.; Ozensoy, Emrah (Elsevier BV, 2014-07-30)
Polystyrene cross-linked divinyl benzene (PS-co-DVB) microspheres were used as an organic template in order to synthesize photocatalytic TiO2 microspheres and microbowls. Photocatalytic activity of the microbowl surfaces were demonstrated both in the gas phase via photocatalytic NO(g) oxidation by O-2(g) as well as in the liquid phase via Rhodamine B degradation. Thermal degradation mechanism of the polymer template and its direct influence on the TiO2 crystal structure, surface morphology, composition, spe...
Preparation, modification, and characterization of acrylic cements
Basgorenay, B; Ulubayram, K; Serbetci, K; Onurhan, E; Hasırcı, Nesrin (2006-03-15)
Acrylic cements with different compositions were prepared by mixing the solid part (composed of poly(methyl methacrylate), PMMA, and benzoyl peroxide, BPO) and the liquid part (composed of methyl methacrylate, MMA, and N,N-dimethyl-p-toluidine, DMPT), modified by addition of hydroxyapatite (HA) and ammonium nitrate (AN) and characterized by measuring thermal and mechanical properties. Three sets of samples were prepared. For B-group, the total amount of solid including HA was constant but the PMMA to HA rat...
Bostancı, Nazlı Seray; Tezcaner, Ayşen; Hasırcı, Nesrin; Department of Biotechnology (2021-8-10)
The aim of this study was to develop an easily applicable and bioactive skin graft composed of methacrylated pectin (PeMA) and methacrylated gelatin (GelMA), containing curcumin and/or Vitamin-C as antimicrobial and healing accelerating agents, respectively. Grafts were prepared in slab, 3D printed and 3D bioprinted forms and different properties were evaluated. Preparation parameters were optimized using slabs having different compositions (PeMA:GelMA as P:G 1:1, 1:2 and 1:3, v/v). P1:G1 solution did not h...
Citation Formats
B. Yilmaz, Z. Evis, A. Tezcaner, and S. Banerjee, “Surface Characterization and Biocompatibility of Selenium-Doped Hydroxyapatite Coating on Titanium Alloy,” INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, pp. 1059–1068, 2016, Accessed: 00, 2020. [Online]. Available: