Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration

Date

2019-08-01

Author

Salman, Huseyin Enes
Yazıcıoğlu, Yiğit

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

176
views

0
downloads

Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibility of noninvasive acoustic detection of the peripheral arterial stenosis is investigated using the vibration responses by means of experimental and computational models. Latex rubber tube is used to model the artery, and it is surrounded by a tissue mimicking phantom made of bovine gelatin. Vibration responses on phantom surface are measured using laser Doppler vibrometer, and computational results are obtained performing modal analysis. Experimental findings and computational results showed well agreement in terms of spectral content and vibration amplitudes. The effects of various stenosis severities, flow rates, and phantom thicknesses on the vibration responses are investigated from diagnostic perspective. Stenosis severities greater than 70% resulted in a considerable increase in vibration amplitudes. The structural mode shapes of the tissue phantom are dominant between 0 and 100 Hz, suppressing the signals generated by the stenosis. The optimum range of frequency for acoustic stenosis detection is concluded to be between 200 and 500 Hz, particularly around 300 Hz.

Subject Keywords

Biomedical Engineering, Computer Science Applications

URI

https://hdl.handle.net/11511/34600

Journal

Medical and Biological Engineering and Computing

DOI

https://doi.org/10.1007/s11517-019-01995-y

Collections

Department of Mechanical Engineering, Article

Suggestions

OpenMETU
Core

Computational analysis for non-invasive detection of stenosis in peripheral arteries Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Elsevier BV, 2019-08-01) Atherosclerosis usually affects the entire cardiovascular system, including peripheral blood vessels. Peripheral arterial stenosis may indicate possible serious vascular disorders related to more vital organs. If peripheral arterial stenosis can be discerned at an early stage, it can serve as a warning sign to take precautions, such as using more invasive diagnostic techniques or adopting a healthier life style. In this study, peripheral regions, such as the thigh, upper arm, and neck are modelled consideri...
Evaluation of multivariate adaptive non-parametric reduced-order model for solving the inverse electrocardiography problem: a simulation study Onak, Onder Nazim; Serinağaoğlu Doğrusöz, Yeşim; Weber, Gerhard Wilhelm (Springer Science and Business Media LLC, 2019-05-01) In the inverse electrocardiography (ECG) problem, the goal is to reconstruct the heart's electrical activity from multichannel body surface potentials and a mathematical model of the torso. Over the years, researchers have employed various approaches to solve this ill-posed problem including regularization, optimization, and statistical estimation. It is still a topic of interest especially for researchers and clinicians whose goal is to adopt this technique in clinical applications. Among the wide range of...
Effect of stenosis shape on the sound emitted from a constricted blood vessel Ozden, Kamil; Sert, Cüneyt; Yazıcıoğlu, Yiğit (Springer Science and Business Media LLC, 2020-03-01) Effect of stenosis shape on the post-stenotic pressure fluctuations and the sound emitted from a constricted blood vessel is studied numerically. Large eddy simulations are performed using OpenFOAM under pulsatile flow conditions with a non-Newtonian fluid model. Findings indicate that the high slope at the stenosis entrance and overlap of more than one stenosis shorten the length of the flow jet, trigger turbulence, and increase vortical activity, turbulent kinetic energy, and magnitude of pressure fluctua...
Effectiveness of topical use of natural polyphenols for the treatment of sacrococcygeal pilonidal sinus disease: a retrospective study including 192 patients Aksoy, Hasan Mete; Aksoy, Berna; Egemen, Didem (John Libbey Eurotext, 2010-07-01) Sacrococcygeal pilonidal sinus disease (SPSD) is a common disorder. None of the current treatment methods seems to be the ideal treatment for SPSD. In this study, we evaluated the effectiveness of polyphenols produced from the components of natural organic matter in soil in the treatment of SPSD. One hundred and ninety two patients with SPSD who used topical polyphenols for the treatment of their disease were studied retrospectively. Information on the characteristics of patients and treatment and results o...
Interdependence of pulsed ultrasound and shear stress effects on cell morphology and gene expression Mccormick, Susan M.; Saini, Vikas; Yazıcıoğlu, Yiğit; Demou, Zoe N.; Royston, Thomas J. (Springer Science and Business Media LLC, 2006-03-01) Fluid shear stress is a key biomechanical regulatory factor in a several biological systems including bone tissue. Bone cells are also regulated by exogenous acoustic vibration, which has therapeutic benefits. In this study, we determined the effects of shear stress and pulsed ultrasound (US), alone and in series on osteoblast morphology and gene expression. We observed that shear stress (19 dyne/cm(2)) elongated SaOS-2 cells at 3, 6, 24, and 48 h decreasing their shape index from control values of 0.51 +/-...

Citation Formats

H. E. Salman and Y. Yazıcıoğlu, “Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration,” Medical and Biological Engineering and Computing, pp. 1737–1752, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/34600.