Effect of stenosis shape on the sound emitted from a constricted blood vessel

Date

2020-03-01

Author

Ozden, Kamil
Sert, Cüneyt
Yazıcıoğlu, Yiğit

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

228
views

0
downloads

Effect of stenosis shape on the post-stenotic pressure fluctuations and the sound emitted from a constricted blood vessel is studied numerically. Large eddy simulations are performed using OpenFOAM under pulsatile flow conditions with a non-Newtonian fluid model. Findings indicate that the high slope at the stenosis entrance and overlap of more than one stenosis shorten the length of the flow jet, trigger turbulence, and increase vortical activity, turbulent kinetic energy, and magnitude of pressure fluctuations at the post-stenotic region. Also, these morphological parameters strengthen the audible signal especially in the systolic phase of the pulsatile flow. On the other hand, asymmetry of the stenosis creates an opposite effect. Based on the wall pressure data, it is shown that the stenosis shape affects the intensity and the pattern of the murmurs generated. Stenosis shape is found to be an essential factor for the acoustic-based non-invasive diagnosis of stenosis.

Subject Keywords

Biomedical Engineering, Computer Science Applications

URI

https://hdl.handle.net/11511/36824

Journal

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

DOI

https://doi.org/10.1007/s11517-020-02119-7

Collections

Department of Mechanical Engineering, Article

Suggestions

OpenMETU
Core

Evaluation of multivariate adaptive non-parametric reduced-order model for solving the inverse electrocardiography problem: a simulation study Onak, Onder Nazim; Serinağaoğlu Doğrusöz, Yeşim; Weber, Gerhard Wilhelm (Springer Science and Business Media LLC, 2019-05-01) In the inverse electrocardiography (ECG) problem, the goal is to reconstruct the heart's electrical activity from multichannel body surface potentials and a mathematical model of the torso. Over the years, researchers have employed various approaches to solve this ill-posed problem including regularization, optimization, and statistical estimation. It is still a topic of interest especially for researchers and clinicians whose goal is to adopt this technique in clinical applications. Among the wide range of...
Interdependence of pulsed ultrasound and shear stress effects on cell morphology and gene expression Mccormick, Susan M.; Saini, Vikas; Yazıcıoğlu, Yiğit; Demou, Zoe N.; Royston, Thomas J. (Springer Science and Business Media LLC, 2006-03-01) Fluid shear stress is a key biomechanical regulatory factor in a several biological systems including bone tissue. Bone cells are also regulated by exogenous acoustic vibration, which has therapeutic benefits. In this study, we determined the effects of shear stress and pulsed ultrasound (US), alone and in series on osteoblast morphology and gene expression. We observed that shear stress (19 dyne/cm(2)) elongated SaOS-2 cells at 3, 6, 24, and 48 h decreasing their shape index from control values of 0.51 +/-...
Effect of solvent refractive index on the surface plasmon resonance nanoparticle optical absorption Ertaş, Gülay (American Scientific Publishers, 2007-12-01) Optical properties of plasmon coupled silver and gold nanoparticles were studied as a function of the refractive index of the surrounding medium. Our studies confirmed that the effect of changes in the refractive index of the surrounding medium was more difficult to demonstrate from an experimental point of view, because of the very high susceptibility of nanoparticles to aggregate in aqueous and organic solvents. Whereas the position of the absorption bands of triiodide in these solvents shows a clear depe...
Effects of different inter-implant distances on the stress distribution around endosseous implants in posterior mandible: A 3D finite element analysis Simsek, B; Erkmen, E; Yilmaz, D; Eser, A (Elsevier BV, 2006-04-01) Purpose: The aim of this study was to evaluate the effects of different inter-implant distances on stress distribution in the bone around the endosseous titanium implants under vertical, oblique and horizontal loads in the posterior mandibular edentulousim by finite element analysis (3D FEA).
Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Springer Science and Business Media LLC, 2019-08-01) Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibility of noninvasive acoustic detection of the peripheral arterial stenosis is investigated using the vibration responses by means of experimental and computational models. Latex rubber tube is u...

Citation Formats

K. Ozden, C. Sert, and Y. Yazıcıoğlu, “Effect of stenosis shape on the sound emitted from a constricted blood vessel,” MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, pp. 643–658, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36824.