Mechanisms of Dietary Response in Mice and Primates: A Role for EGR1 in Regulating the Reaction to Human-Specific Nutritional Content

Weng, Kai
Hu, Haiyang
Xu, Augix Guohua
Khaitovich, Philipp
Somel, Mehmet
Background: Humans have a widely different diet from other primate species, and are dependent on its high nutritional content. The molecular mechanisms responsible for adaptation to the human diet are currently unknown. Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees.


Human and Chimpanzee Gene Expression Differences Replicated in Mice Fed Different Diets
Somel, Mehmet; Franz, Henriette; Mueller, Uwe; Lachmann, Michael; Khaitovich, Philipp; Paeaebo, Svante (2008-01-30)
Although the human diet is markedly different from the diets of closely related primate species, the influence of diet on phenotypic and genetic differences between humans and other primates is unknown. In this study, we analyzed gene expression in laboratory mice fed diets typical of humans and of chimpanzees. The effects of human diets were found to be significantly different from that of a chimpanzee diet in the mouse liver, but not in the brain. Importantly, 10% of the genes that differ in their express...
Evolution of Self-Organized Task Specialization in Robot Swarms
Ferrante, Eliseo; Turgut, Ali Emre; Duenez-Guzman, Edgar; Dorigo, Marco; Wenseleers, Tom (Public Library of Science (PLoS), 2015-08-01)
Division of labor is ubiquitous in biological systems, as evidenced by various forms of complex task specialization observed in both animal societies and multicellular organisms. Although clearly adaptive, the way in which division of labor first evolved remains enigmatic, as it requires the simultaneous co-occurrence of several complex traits to achieve the required degree of coordination. Recently, evolutionary swarm robotics has emerged as an excellent test bed to study the evolution of coordinated group...
Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors.
Coban, C; Ishii, KJ; Gürsel, Mayda; Klinman, DM; Kumar, N (Wiley, 2005-09-01)
DNA vaccines, in general, have been found to be poorly immunogenic in nonhuman primates and humans as compared with mice. As the immunogenicity of DNA plasmids relies, to a large extent, on the presence of CpG motifs as built in adjuvants, we addressed the issue of poor immunogenicity by inserting recently identified CpG oligonucleotides (ODN) optimal for human (K-type or D-type CpG ODN) into the backbone of plasmid VR1020. We found that plasmid DNA containing K-type CpG motifs or D-type CpG motifs signific...
A Comparison of Brain Gene Expression Levels in Domesticated and Wild Animals
Albert, Frank W.; Somel, Mehmet; Carneiro, Miguel; Aximu-Petri, Ayinuer; Halbwax, Michel; Thalmann, Olaf; Blanco-Aguiar, Jose A.; Plyusnina, Irina Z.; Trut, Lyudmila; Villafuerte, Rafael; Ferrand, Nuno; Kaiser, Sylvia; Jensen, Per; Paeaebo, Svante (2012-09-01)
Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs...
Effects of Crucian Carp (Carassius auratus) on Water Quality in Aquatic Ecosystems: An Experimental Mesocosm Study
Huang, Yehui; Mei, Xueying; Rudstam, Lars G.; Taylor, William D.; Urabe, Jotaro; Jeppesen, Erik; Liu, Zhengwen; Zhang, Xiufeng (MDPI AG, 2020-5-19)
The presence of omnivorous fish is known to affect aquatic ecosystems, including water quality. The effect, however, depends on the species in question, and our knowledge is limited on the effect of omnivorous crucian carp (Carassius auratus), a common and often the most numerous fish species in eutrophic shallow lakes in China. We conducted a 70-day outdoor experiment in mesocosms with and without crucian carp to examine whether this species adversely affects water quality by increasing the levels of total...
Citation Formats
K. Weng, H. Hu, A. G. Xu, P. Khaitovich, and M. Somel, “Mechanisms of Dietary Response in Mice and Primates: A Role for EGR1 in Regulating the Reaction to Human-Specific Nutritional Content,” PLOS ONE, pp. 0–0, 2012, Accessed: 00, 2020. [Online]. Available: