Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities

Date

2011-06-01

Author

Doğan, Özdemir
Gözen, Ayşe Gül

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A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.

Subject Keywords

Organic Chemistry, Pharmacology, Drug Discovery, General Medicine

URI

https://hdl.handle.net/11511/35076

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DOI

https://doi.org/10.1016/j.ejmech.2011.03.037

Collections

Department of Chemistry, Article

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Citation Formats

Ö. Doğan and A. G. Gözen, “Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities,” EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 2485–2489, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/35076.